Liu Sizhuo, Deng Tinghan, Cheng Hongbin, Lu Jun, Wu Jingping
School of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 610032, China.
Traditional Chinese Medicine Hospital of Sichuan Province, Chengdu 610072, China.
Pharmaceutics. 2025 Jun 6;17(6):746. doi: 10.3390/pharmaceutics17060746.
Inflammatory skin diseases are highly prevalent conditions characterized by complex immune responses that result in skin tissue damage and pain, significantly impacting patients' physical health. Traditional therapeutic approaches, including oral administration and injections, continue to exhibit inherent limitations. Consequently, there is growing interest in exploring alternative drug delivery systems that offer more effective, targeted, and patient-friendly therapeutic options. Transdermal administration emerges as a promising solution for managing inflammatory skin diseases, facilitating sustained drug release, and reducing the frequency of dosing. This review provides a comprehensive overview of the skin barrier and critically summarizes clinically adopted transdermal drug delivery systems (TDDSs), including sonophoresis, iontophoresis, chemical penetration enhancers, and electroporation. Particular emphasis is placed on emerging advances in microneedle- and nanocarrier-facilitated transdermal delivery strategies. Moreover, the article synthesizes recent fundamental evidence regarding the application of TDDSs in the treatment of atopic dermatitis, psoriasis, and acne. This review examines fundamental research evaluating various transdermal drug delivery systems for the treatment of major inflammatory skin diseases, with an emphasis on their mechanisms of action, advantages, challenges, and future directions. Transdermal drug delivery systems hold the potential to deliver more efficient and safer treatment and management strategies for patients afflicted with inflammatory skin diseases.
炎症性皮肤病是高度常见的病症，其特征为导致皮肤组织损伤和疼痛的复杂免疫反应，对患者的身体健康有重大影响。包括口服给药和注射在内的传统治疗方法仍然存在固有的局限性。因此，人们越来越有兴趣探索替代药物递送系统，以提供更有效、有针对性且对患者友好的治疗选择。透皮给药成为治疗炎症性皮肤病、促进药物持续释放以及减少给药频率的一种有前景的解决方案。本综述全面概述了皮肤屏障，并批判性地总结了临床采用的透皮给药系统（TDDS），包括超声导入法、离子导入法、化学渗透促进剂和电穿孔。特别强调了微针和纳米载体促进的透皮递送策略的新进展。此外，本文综合了关于TDDS在治疗特应性皮炎、银屑病和痤疮方面应用的最新基础证据。本综述审视了评估各种透皮给药系统治疗主要炎症性皮肤病的基础研究，重点关注其作用机制、优点、挑战和未来方向。透皮给药系统有潜力为患有炎症性皮肤病的患者提供更高效、更安全的治疗和管理策略。
