Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Department of Physiotherapy, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
J Parkinsons Dis. 2024;14(6):1193-1210. doi: 10.3233/JPD-240071.
Exercise promotion interventions for people with Parkinson's disease (PD) are often offered on a face-to-face basis, follow a generic "one-size-fit-all" approach, and are not typically delivered at diagnosis. Considering PD's heterogenous nature, the existing evidence on the merits of exercise on symptom management and the expressed wishes of people living with PD for access to timely and tailored evidence-based information, there is a demand for interventions that are easily accessible, scalable and co-designed with people living with PD.
Evaluate the feasibility and acceptability of a co-designed digital intervention promoting exercise and physical activity, in people newly diagnosed with PD.
Thirty people living with PD for less than one year participated in an assessor-blinded randomized feasibility trial from June 2022 to April 2023. The intervention group received the 8-week Knowledge, Exercise Efficacy and Participation (KEEP) intervention comprising 6 interactive digital modules and 4 online live group discussions facilitated by a specialist physiotherapist. Assessments were performed at baseline, post intervention and at 6-month follow up.
Thirty participants were recruited to target with a 64% recruitment rate (30/47). All but one participant completed the 6-month follow-up assessment. There was high retention (97%), module completion (91%), and online discussion attendance (88%). Outcome measure collection was feasible, including accelerometer data with a daily average wear time of 23.9 hours (SD:0.295).
The KEEP intervention was feasible and acceptable in people newly diagnosed with PD. A larger trial is needed to assess intervention efficacy and correlation between knowledge, self-efficacy, and activity levels.
针对帕金森病（PD）患者的运动促进干预措施通常以面对面的方式提供，遵循通用的“一刀切”方法，且通常不在诊断时提供。考虑到 PD 的异质性，现有的关于运动对症状管理的益处的证据，以及患者对及时获得基于证据的量身定制信息的愿望，因此需要易于获取、可扩展且与患者共同设计的干预措施。
评估针对新诊断为 PD 的患者的共同设计的数字干预措施促进运动和身体活动的可行性和可接受性。
30 名 PD 患者在 2022 年 6 月至 2023 年 4 月期间参与了一项评估者盲法随机可行性试验。干预组接受了为期 8 周的知识、运动效能和参与（KEEP）干预，包括 6 个互动数字模块和 4 次由专业物理治疗师主持的在线小组讨论。在基线、干预后和 6 个月随访时进行评估。
共招募了 30 名目标参与者，招募率为 64%（30/47）。除 1 名参与者外，所有人均完成了 6 个月随访评估。保留率高（97%），模块完成率（91%）和在线讨论出勤率（88%）。包括加速度计数据在内的结局测量收集是可行的，日常平均佩戴时间为 23.9 小时（SD：0.295）。
KEEP 干预措施在新诊断为 PD 的患者中是可行且可接受的。需要更大规模的试验来评估干预效果以及知识、自我效能感和活动水平之间的相关性。
