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基于血流冲击原理的心脏支架数值建模与分析。

Numerical modeling and analysis of cardiac stent using blood hammer principle.

机构信息

School of Arts Sciences, Humanities and Education, SASTRA Deemed University, Thanjavur, Tamil Nadu, India.

School of Chemical and Biotechnology, SASTRA Deemed University, Thanjavur, Tamil Nadu, India.

出版信息

Technol Health Care. 2024;32(6):4223-4238. doi: 10.3233/THC-240051.

DOI:10.3233/THC-240051
PMID:39093086
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11613089/
Abstract

BACKGROUND

Atherosclerosis is a condition which disrupts blood flow due to plaque build-up inside the arteries. Under conditions where consecutive plaques are prevailing blood hammer principle is exhibited.

OBJECTIVE

The pressure and shear stress produced at an infinitesimal area act as the governing equation for stent modeling. The leading order pressure lays the foundation for the design of cardiac stents with definite dimensions.

METHOD

The designed stent was encapsulated inside a crimper validated through ANSYS-static and transient structural simulation to derive the total deformation, equivalent strain, and stress exerted on the stent. Five different biomaterials stainless steel 316, cobalt, chromium, platinum, and Poly lactic acid were selected for the material assessment.

RESULT

Static and Transient structural analysis for a period of 1 and 10 secs was implemented for a stent with and without a crimper. The material performance in terms of total deformation, equivalent stress, and strain are analyzed.

CONCLUSION

The paper envisions the dynamics of blood hammer in atherosclerosis that provides the changes in the pressure and clotting process. It shows the promising results of the stent behavior in varied forces which gives valuable insights for future improvement in stent design and material selection.

摘要

背景

动脉粥样硬化是一种由于动脉内部斑块积聚而导致血流中断的疾病。在连续斑块占主导地位的情况下,会出现血液锤击原理。

目的

在微小面积上产生的压力和剪切应力是支架建模的控制方程。主导压力为具有确定尺寸的心脏支架设计奠定了基础。

方法

设计的支架被封装在一个验证通过 ANSYS 静态和瞬态结构模拟的压接器中,以得出支架上的总变形、等效应变和所施加的应力。选择了五种不同的生物材料不锈钢 316、钴、铬、铂和聚乳酸来进行材料评估。

结果

对带有和不带有压接器的支架进行了 1 秒和 10 秒的静态和瞬态结构分析。分析了材料在总变形、等效应力和应变方面的性能。

结论

本文预见了动脉粥样硬化中血液锤击的动力学,提供了压力和凝血过程的变化。它展示了支架在不同力下的良好行为,为未来改进支架设计和材料选择提供了有价值的见解。

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本文引用的文献

1
An Experimental and Simulation Study of the Active Camber Morphing Concept on Airfoils Using Bio-Inspired Structures.基于生物启发结构的翼型主动弯度变形概念的实验与仿真研究
Biomimetics (Basel). 2023 Jun 13;8(2):251. doi: 10.3390/biomimetics8020251.
2
Patient-specific computational simulation of coronary artery bifurcation stenting.冠状动脉分叉支架的个体化计算模拟。
Sci Rep. 2021 Aug 13;11(1):16486. doi: 10.1038/s41598-021-95026-2.
3
Fibrin Clot Properties in Atherosclerotic Vascular Disease: From Pathophysiology to Clinical Outcomes.动脉粥样硬化性血管疾病中的纤维蛋白凝块特性:从病理生理学到临床结果
J Clin Med. 2021 Jul 5;10(13):2999. doi: 10.3390/jcm10132999.
4
Structural Design of Vascular Stents: A Review.血管支架的结构设计:综述
Micromachines (Basel). 2021 Jun 29;12(7):770. doi: 10.3390/mi12070770.
5
3D printing materials and their use in medical education: a review of current technology and trends for the future.3D打印材料及其在医学教育中的应用:当前技术与未来趋势综述
BMJ Simul Technol Enhanc Learn. 2018 Jan;4(1):27-40. doi: 10.1136/bmjstel-2017-000234. Epub 2017 Oct 21.
6
Biocompatibility of Coronary Stents.冠状动脉支架的生物相容性
Materials (Basel). 2014 Jan 28;7(2):769-786. doi: 10.3390/ma7020769.
7
Atherosclerosis: process, indicators, risk factors and new hopes.动脉粥样硬化:进程、指标、风险因素与新希望
Int J Prev Med. 2014 Aug;5(8):927-46.
8
Therapeutic approaches to drug targets in atherosclerosis.动脉粥样硬化的药物靶点治疗方法。
Saudi Pharm J. 2014 Jul;22(3):179-90. doi: 10.1016/j.jsps.2013.04.005. Epub 2013 Nov 5.
9
Biomaterial applications in cardiovascular tissue repair and regeneration.生物材料在心血管组织修复与再生中的应用。
Expert Rev Cardiovasc Ther. 2012 Aug;10(8):1039-49. doi: 10.1586/erc.12.99.
10
Computational structural modelling of coronary stent deployment: a review.冠状动脉支架展开的计算结构建模:综述
Comput Methods Biomech Biomed Engin. 2011 Apr;14(4):331-48. doi: 10.1080/10255841003766845.