Lam Mai T, Wu Joseph C
Department of Surgery, Division of Plastic and Reconstructive Surgery, Hagey Pediatric Regenerative Research Laboratory, Stanford University School of Medicine, Stanford, CA, USA.
Expert Rev Cardiovasc Ther. 2012 Aug;10(8):1039-49. doi: 10.1586/erc.12.99.
Cardiovascular disease physically damages the heart, resulting in loss of cardiac function. Medications can help alleviate symptoms, but it is more beneficial to treat the root cause by repairing injured tissues, which gives patients better outcomes. Besides heart transplants, cardiac surgeons use a variety of methods for repairing different areas of the heart such as the ventricular septal wall and valves. A multitude of biomaterials are used in the repair and replacement of impaired heart tissues. These biomaterials fall into two main categories: synthetic and natural. Synthetic materials used in cardiovascular applications include polymers and metals. Natural materials are derived from biological sources such as human donor or harvested animal tissues. A new class of composite materials has emerged to take advantage of the benefits of the strengths and minimize the weaknesses of both synthetic and natural materials. This article reviews the current and prospective applications of biomaterials in cardiovascular therapies.
心血管疾病会对心脏造成物理损伤，导致心脏功能丧失。药物可以帮助缓解症状，但通过修复受损组织来治疗根本原因更有益，这能给患者带来更好的治疗效果。除了心脏移植，心脏外科医生使用多种方法修复心脏的不同部位，如室间隔壁和瓣膜。在受损心脏组织的修复和替换中使用了多种生物材料。这些生物材料主要分为两类：合成材料和天然材料。用于心血管应用的合成材料包括聚合物和金属。天然材料来源于生物源，如人类供体或采集的动物组织。一类新型复合材料应运而生，以利用合成材料和天然材料各自的优势，并将两者的劣势降至最低。本文综述了生物材料在心血管治疗中的当前及未来应用。
