[久坐行为对智利成年人FTO基因与肥胖水平之间相互作用的影响——GENADIO研究结果]

[Effect of Sedentary behaviors on the Interaction Between the FTO Gene and Adiposity Levels in Chilean Adults - Results from the GENADIO Study].

作者信息

Celis-Morales Carlos, Villagrán Marcelo, Mardones Lorena, Martínez-Sanguinetti María Adela, Leiva-Ordoñez Ana María, Carrasco-Marín Fernanda, Ulloa Natalia, Martorell Miquel, Lasserre-Laso Nicole, Díaz-Martinez Ximena, Cigarroa Igor, Concha-Cisternas Yeny, Troncoso-Pantoja Claudia, Lanuza Fabian, Vásquez-Gómez Jaime, Parra-Soto Solange, Petermann-Rocha Fanny

机构信息

School of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, United Kingdom.

Laboratorio de Investigación en Ciencias Biomédicas, Facultad de Medicina, Universidad Católica de la Santísima Concepción, Concepción, Chile.

出版信息

Rev Med Chil. 2023 Aug;151(8):980-991. doi: 10.4067/s0034-98872023000800980.

DOI:10.4067/s0034-98872023000800980

PMID:39093190

Abstract

BACKGROUND

The Fat-mass and obesity-associated-gene (FTO gene) and sedentary behavior time are associated with obesity. However, whether sedentary behavior time can modify the genetic predisposition to obesity in the Chilean population is unknown. Therefore, this study investigated the association between sedentary behavior, adiposity markers, and the FTO gene.

METHODS

This cross-sectional study included 409 participants from the Genes, Environment, Diabetes, and Obesity (GENADIO) study. Adiposity markers studied included body weight, body mass index (BMI), waist circumference (WC), and fat mass. Sedentary behaviors were measured using accelerometers. Using multiple regression, we evaluated the interaction between sedentary behaviors and the FTO gene (rs9939609) on adiposity markers.

RESULTS

Sedentary behaviors and the FTO genotype were positively associated with higher body weight, BMI, WC, and fat mass. However, the association between time of sedentary behavior and adiposity markers was higher in carriers of the risk variant for the FTO gene. For each hour of increment in sedentary behaviors, body weight increases by 1.36 kg ([95% CI: 0.27; 2.46], p = 0.015) and 2.95 kg ([95%CI: 1.24; 4.65], p = 0.001) in non-risk carriers (TT) versus risk carriers (AA), respectively. We observed similar results for WC, BMI, and body fat, but the interaction was significant only for WC.

CONCLUSION

The association between sedentary behaviors and adiposity markers, especially body weight and WC, is higher in individuals who carry the risk variant of the FTO gene.

摘要

背景

脂肪量与肥胖相关基因（FTO基因）以及久坐行为时间与肥胖有关。然而，在智利人群中，久坐行为时间是否会改变肥胖的遗传易感性尚不清楚。因此，本研究调查了久坐行为、肥胖标志物与FTO基因之间的关联。

方法

这项横断面研究纳入了来自基因、环境、糖尿病和肥胖（GENADIO）研究的409名参与者。所研究的肥胖标志物包括体重、体重指数（BMI）、腰围（WC）和脂肪量。使用加速度计测量久坐行为。通过多元回归，我们评估了久坐行为与FTO基因（rs9939609）对肥胖标志物的相互作用。

结果

久坐行为和FTO基因型与较高的体重、BMI、WC和脂肪量呈正相关。然而，在FTO基因风险变异携带者中，久坐行为时间与肥胖标志物之间的关联更高。对于久坐行为每增加一小时而言，非风险携带者（TT）的体重分别增加1.36千克（[95%置信区间：（0.27；2.46）]，p = 0.015），而风险携带者（AA）体重增加2.95千克（[95%置信区间：（1.24；4.65）]，p = 0.001）。我们在WC、BMI和体脂方面观察到了类似结果，但这种相互作用仅对WC具有显著意义。