[智利成年人中FTO（ns9939609）基因型与肥胖标志物之间的关联]

[Association between FTO (ns9939609) genotype and adiposity markers in Chilean adults].

作者信息

Petermann Fanny, Villagrán Marcelo, Troncoso Claudia, Mardones Lorena, Leiva Ana María, Martínez María Adela, Garrido-Méndez Alex, Poblete-Valderrama Felipe, Salas-Bravo Carlos, Ramírez-Vélez Robinson, Ulloa Natalia, Pérez-Bravo Francisco, Celis-Morales Carlos

机构信息

BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom.

Departamento de Ciencias Básicas, Universidad Católica de la Santísima Concepción, Concepción, Chile.

出版信息

Rev Med Chil. 2018 Jun;146(6):717-726. doi: 10.4067/s0034-98872018000600717.

DOI:10.4067/s0034-98872018000600717

PMID:30148903

Abstract

BACKGROUND

Numerous studies have identified the role of Fat-mass-associated-gene (FTO) in the development of obesity.

AIM

To investigate the association of FTO gene with adiposity markers in Chilean adults.

MATERIAL AND METHODS

409 participants were included in this cross-sectional study. The association between FTO (rs9939609) genotype and adiposity markers was determined using linear regression analyses. Adiposity markers included were: body weight, body mass index, fat mass, waist circumference, hip circumference and waist/hip ratio.

RESULTS

A fully adjusted model showed a significant association between FTO genotype and body weight (2.16 kg per each extra copy of the risk allele [95% confidence intervals (CI): 0.45 to 3.87], p = 0.014), body mass index (0.61 kg.m-2 [95% CI: 0.12 to 1.20], p = 0.050) and fat mass (1.14% [95% CI: 0.39 to 1.89], p = 0.010). The greater magnitude of association was found between the FTO gene and fat mass when the outcomes were standardized to z-score.

CONCLUSIONS

This study confirms an association between the FTO gene and adiposity markers in Chilean adults, which is independent of major confounding factors.

摘要

背景

众多研究已确定脂肪量相关基因（FTO）在肥胖症发展中的作用。

目的

研究智利成年人中FTO基因与肥胖标志物之间的关联。

材料与方法

本横断面研究纳入了409名参与者。使用线性回归分析确定FTO（rs9939609）基因型与肥胖标志物之间的关联。纳入的肥胖标志物包括：体重、体重指数、脂肪量、腰围、臀围和腰臀比。

结果

一个完全调整后的模型显示，FTO基因型与体重（风险等位基因每多一份增加2.16千克[95%置信区间（CI）：0.45至3.87]，p = 0.014）、体重指数（0.61千克·米-2[95%CI：0.12至1.20]，p = 0.050）和脂肪量（1.14%[95%CI：0.39至1.89]，p = 0.010）之间存在显著关联。当将结果标准化为z分数时，发现FTO基因与脂肪量之间的关联程度更大。