Scully B E, Ores C N, Prince A S, Neu H C
Rev Infect Dis. 1985 Nov-Dec;7 Suppl 4:S669-74. doi: 10.1093/clinids/7.supplement_4.s669.
Twelve patients who underwent 26 episodes of lower respiratory tract infection due to Pseudomonas aeruginosa were treated with aztreonam. Infectious episodes were severe in 11 patients, moderate in 10 patients, and mild in five patients. In 85% of the episodes, significant clinical improvement occurred, but in four severe episodes, the clinical response was unsatisfactory. The mean interval between initiation of treatment and improvement was seven days. Aztreonam was as clinically effective in the treatment of infections due to organisms susceptible to penicillins active against Pseudomonas as it was in the treatment of infections due to organisms resistant to these agents. P. aeruginosa was not permanently eradicated from the sputum of any of the patients treated with aztreonam. It did not cause any major adverse effects, and the only laboratory abnormality found was an increase in alkaline phosphatase, which occurred during 12 (46%) courses of therapy. Levels of alkaline phosphatase returned to normal after conclusion of treatment. Aztreonam was shown to be clinically effective in the treatment of lower respiratory infections due to P. aeruginosa in patients with cystic fibrosis.
12例因铜绿假单胞菌引起26次下呼吸道感染的患者接受了氨曲南治疗。11例患者的感染发作严重，10例患者中度感染，5例患者轻度感染。在85%的发作中，出现了显著的临床改善，但在4次严重发作中，临床反应不令人满意。治疗开始至改善的平均间隔时间为7天。氨曲南在治疗对青霉素敏感的铜绿假单胞菌感染时与治疗对这些药物耐药的细菌感染时临床效果一样好。在接受氨曲南治疗的任何患者的痰液中，铜绿假单胞菌都未被永久根除。它未引起任何重大不良反应，唯一发现的实验室异常是碱性磷酸酶升高，这在12个疗程（46%）中出现。治疗结束后碱性磷酸酶水平恢复正常。氨曲南在治疗囊性纤维化患者因铜绿假单胞菌引起的下呼吸道感染方面显示出临床疗效。
