Malmborg A S, Alfredsson H, Kusoffsky E, Strandvik B
Scand J Infect Dis Suppl. 1981;29:64-9.
Azlocillin, 200 mg/kg bodyweight every 8 h, and gentamicin, 2.5-4 mg/kg bodyweight every 12 h, in combination were given intravenously to 10 patients with cystic fibrosis for at least 10 days. The patients were colonized with Pseudomonas aeruginosa and were hospitalized due to symptoms of lower respiratory tract infections. Using an agar well diffusion method the antibiotic concentrations were followed in serum and sputum. The individual sputum concentration of azlocillin varied during 4 h after administration from less than 1.5 to 38 micrograms/ml. The sputum concentration of gentamicin varied from 0.3 to 1.1 micrograms/ml. P. aeruginosa was apparently eliminated in 3 patients. The concentration of the antibiotics in sputum could not predict the outcome of treatment. All patients improved subjectively. No adverse effect was seen.
对10例囊性纤维化患者静脉联合使用阿洛西林（每8小时200mg/kg体重）和庆大霉素（每12小时2.5 - 4mg/kg体重），疗程至少10天。这些患者感染了铜绿假单胞菌，因下呼吸道感染症状而住院。采用琼脂孔扩散法监测血清和痰液中的抗生素浓度。给药后4小时内，阿洛西林在痰液中的个体浓度从低于1.5微克/毫升至38微克/毫升不等。庆大霉素在痰液中的浓度从0.3微克/毫升至1.1微克/毫升不等。3例患者体内的铜绿假单胞菌明显被清除。痰液中抗生素的浓度无法预测治疗结果。所有患者主观上均有改善。未观察到不良反应。
