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蛋白激酶 A 抑制剂减弱 NMDA 受体通道拮抗剂在辣椒素试验中对小鼠的镇痛作用。

Protein Kinase A Inhibitor Attenuates the Antinociceptive Effect of NMDA-Receptor Channel Antagonists in the Capsaicin Test in Mice.

机构信息

V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia.

出版信息

Bull Exp Biol Med. 2024 Jun;177(2):231-234. doi: 10.1007/s10517-024-06162-4. Epub 2024 Aug 2.

DOI:10.1007/s10517-024-06162-4
PMID:39093477
Abstract

Acute nociceptive pain in mice caused by subcutaneous (intraplantar) injection of TRPV1 ion channel agonist capsaicin (1.6 μg/mouse) and the effects of protein kinase A inhibitor H-89 (0.05 mg/mouse, intraplantar injection) and NMDA receptor channel antagonists MK-801 (7.5 and 15 μg/mouse, topical application) and hemantane (0.5 mg/mouse, topical application) on the pain were assessed. MK-801 and hemantane were found to reduce the duration of the pain response. H-89 did not significantly affect the pain in animals, but preliminary administration of this drug abolished the antinociceptive effect of MK-801 (7.5 μg/mouse) and weakens the effect of hemantane (0.5 mg/mouse).

摘要

评估了 TRPV1 离子通道激动剂辣椒素（1.6 μg/只，皮下注射）引起的小鼠急性伤害性疼痛以及蛋白激酶 A 抑制剂 H-89（0.05 mg/只，皮下注射）和 NMDA 受体通道拮抗剂 MK-801（7.5 和 15 μg/只，局部应用）和 hemantane（0.5 mg/只，局部应用）对疼痛的影响。MK-801 和 hemantane 被发现可缩短疼痛反应的持续时间。H-89 对动物的疼痛没有明显影响，但该药物的初步给药消除了 MK-801（7.5 μg/只）的抗伤害作用，并减弱了 hemantane（0.5 mg/只）的作用。

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