TRPV1：结构、内源性激动剂和作用机制。

Departamento de Neurociencia Cognitiva, División Neurociencias, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Mexico City 04510, Mexico.

Int J Mol Sci. 2020 May 12;21(10):3421. doi: 10.3390/ijms21103421.

The Transient Receptor Potential Vanilloid 1 (TRPV1) channel is a polymodal protein with functions widely linked to the generation of pain. Several agonists of exogenous and endogenous nature have been described for this ion channel. Nonetheless, detailed mechanisms and description of binding sites have been resolved only for a few endogenous agonists. This review focuses on summarizing discoveries made in this particular field of study and highlighting the fact that studying the molecular details of activation of the channel by different agonists can shed light on biophysical traits that had not been previously demonstrated.

瞬时受体电位香草酸 1 型通道（TRPV1）是一种多模态蛋白，其功能与疼痛的产生广泛相关。已经描述了这种离子通道的几种外源性和内源性激动剂。然而，只有少数内源性激动剂的详细结合机制和结合位点得到了解决。本综述重点总结了该研究领域的发现，并强调了这样一个事实，即研究不同激动剂激活通道的分子细节可以揭示以前未证明的生物物理特性。