J Drugs Dermatol. 2024 Aug 1;23(8):661-668. doi: 10.36849/JDD.8421.
Hair thinning affects upwards of 50% of women by age 50, impacting their social-emotional wellbeing. It is a condition now thought to be driven by a multi-factorial etiology, including diet and nutrition. Women following vegan, vegetarian, or other plant-based diets have specific needs for nutrients traditionally sourced from animals, which could affect hair health. To support hair growth and quality in women following a plant-based diet, a novel vegan nutraceutical (Nutrafol Women's Vegan Capsules, Nutraceutical Wellness, Inc., New York, NY) was evaluated for its ability to support hair health. The objectives of this 6-month, multi-site, single-blind prospective clinical study was to evaluate the safety and efficacy of the nutraceutical to improve hair growth and quality in women consuming a plant-based diet. The primary endpoint in this study was an increase in terminal hair count at day 180 compared with baseline, as assessed through phototrichogram analysis. Ninety-five subjects completed the study. Daily intake of the nutraceutical resulted in a significant increase in the number of terminal hairs at day 90 (P<0.01) and day 180 (P<0.01). There was also an increase in total hair counts (P<0.01), the terminal-to-vellus ratio (P<0.01), and a decrease in shedding (P<0.01). Global Investigator Ratings revealed improved hair growth (P<0.00001) and overall quality (P<0.00001). In-person hair strength and brittleness assessments significantly improved as well (P<0.01 for both). A significant proportion of subjects reported improved hair quality, appearance, texture, and volume. Hair problems affecting the quality of life of the subjects were also reported as improved. This study demonstrated significant improvements in hair growth and quality in a plant-based population with a vegan nutraceutical. ClinicalTrials.gov Identifier: NCT05332743. J Drugs Dermatol. 2024;23(8):661-668. doi:10.36849/JDD.8421.
头发稀疏影响超过 50%的女性在 50 岁时，影响她们的社会情感健康。现在认为这种情况是由多种因素引起的，包括饮食和营养。遵循纯素、素食或其他植物性饮食的女性对传统上从动物中获取的营养物质有特殊需求，这可能会影响头发健康。为了支持遵循植物性饮食的女性的头发生长和质量，一种新型的纯素营养保健品（Nutrafol Women's Vegan Capsules，Nutraceutical Wellness，Inc.，New York，NY）被评估其支持头发生长健康的能力。这项为期 6 个月、多地点、单盲前瞻性临床研究的目的是评估营养保健品在改善食用植物性饮食的女性头发生长和质量方面的安全性和有效性。本研究的主要终点是通过毛发图像分析评估，与基线相比，第 180 天终毛计数增加。95 名受试者完成了这项研究。每天服用营养保健品可使第 90 天（P<0.01）和第 180 天（P<0.01）的终毛数量显著增加。总发量也有所增加（P<0.01），终毛与毳毛的比例（P<0.01）增加，脱发减少（P<0.01）。全球调查员评分显示，头发生长（P<0.00001）和整体质量（P<0.00001）均有所改善。现场头发强度和脆性评估也显著改善（均为 P<0.01）。相当一部分受试者报告称，头发质量、外观、质地和体积得到改善。报告称，影响受试者生活质量的头发问题也得到改善。这项研究表明，在植物性人群中，一种纯素营养保健品可显著改善头发生长和质量。ClinicalTrials.gov 标识符：NCT05332743。J 皮肤病药物杂志。2024;23(8):661-668。
