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患者血液管理计划实施:全面建议和实用策略。

Patient Blood Management Program Implementation: Comprehensive Recommendations and Practical Strategies.

机构信息

Department of Morphology and Genetics, Discipline of Genetics, Escola Paulista de Medicina, Universidade Federal de São Paulo (UNIFESP), São Paulo, São Paulo, Brazil.

Department of Clinical and Experimental Oncology, Discipline of Hematology and Hemotherapy, Escola Paulista de Medicina, Universidade Federal de São Paulo (UNIFESP), São Paulo, São Paulo, Brazil.

出版信息

Braz J Cardiovasc Surg. 2024 Aug 2;39(5):e20240205. doi: 10.21470/1678-9741-2024-0205.

Abstract

INTRODUCTION

Blood transfusion is one of the most common medical practices worldwide. However, current scientific literature has shown that the immunomodulatory effects of blood transfusion are associated with an increased likelihood of infection, prolonged hospitalization, and morbimortality. Also, it means high costs for healthcare systems.

METHODS

In this context, acknowledging that blood transfusions are essentially heterologous cell transplantations, the use of therapeutic options has gained strength and is collectively known as the patient blood management (PBM) program. PBM is an approach based on three main pillars: (1) treating anemias and coagulopathies in an optimized manner, especially in the preoperative period; (2) optimizing perioperative hemostasis and the use of blood recovery systems to avoid the loss of the patient's blood; (3) anemia tolerance, with improved oxygen delivery and reduced oxygen demand, particularly in the postoperative period.

RESULTS

Current scientific evidence supports the effectiveness of PBM by reducing the need for blood transfusions, decreasing associated complications, and promoting more efficient and safer blood management. Thus, PBM not only improves clinical outcomes for patients but also contributes to the economic sustainability of healthcare systems.

CONCLUSION

The aim of this review was to summarize PBM strategies in a comprehensive, evidence-based approach through a systematic and structured model for PBM implementation in tertiary hospitals. The recommendations proposed herein are from researchers and experts of a high-complexity university hospital in the network of the Sistema Único de Saúde, presenting itself as a strategy that can be followed as a guideline for PBM implementation in other settings.

摘要

简介

输血是全球最常见的医疗实践之一。然而,目前的科学文献表明,输血的免疫调节作用与感染的可能性增加、住院时间延长和发病率死亡率有关。此外,这意味着医疗保健系统的成本很高。

方法

在这种情况下,鉴于输血本质上是同种异体细胞移植,治疗选择的使用得到了加强,并被统称为患者血液管理 (PBM) 计划。PBM 是一种基于三个主要支柱的方法:(1) 以优化的方式治疗贫血和凝血障碍,特别是在术前期间;(2) 优化围手术期止血和使用血液回收系统以避免患者血液流失;(3) 贫血耐受,改善氧输送和降低氧需求,特别是在术后期间。

结果

目前的科学证据支持 PBM 通过减少输血需求、降低相关并发症以及促进更有效和更安全的血液管理的有效性。因此,PBM 不仅改善了患者的临床结果,还有助于医疗保健系统的经济可持续性。

结论

本综述的目的是通过系统和结构化的 PBM 实施模型,全面、基于证据地总结 PBM 策略。本文提出的建议来自高复杂性大学医院的研究人员和专家,该医院是巴西统一卫生系统网络的一部分,它本身就是一种可以遵循的策略,可作为在其他环境中实施 PBM 的指南。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4d4/11296688/d5a740afbad0/bjcvs-39-05-e20240205-g01.jpg

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