Bunin K V, Parfenova N N, Kravtsov E G, Firsanov V I
Zh Mikrobiol Epidemiol Immunobiol. 1979 Dec(12):60-3.
The immunological activity of specific immunoglobulins in different forms of cholera infection was studied with the use of the indirect immunofluorescent method. The forms of cholera infection were shown to be related to the physico-chemical spectrum of antibodies: patients with the pronounced clinical symptoms of cholera produced serum IgM, including antigen -- antibody complex, more actively and in a greater amount; patients with faintly pronounced and asymptomatic infection produce highly active IgG. The competitive action of immunoglobulins of different classes in their simultaneous reaction with O antigen of Vibrio cholerae is shown. The mechanism of the competitive action of different immunoglobulin classes is supposed to play some role in the process of the sanation (with highly active IgM) or detoxication (with highly active IgG) of the organism.
采用间接免疫荧光法研究了不同形式霍乱感染中特异性免疫球蛋白的免疫活性。结果表明，霍乱感染的形式与抗体的理化谱有关：霍乱临床症状明显的患者血清IgM，包括抗原 - 抗体复合物，产生更活跃且量更大；临床症状轻微和无症状感染的患者产生高活性IgG。显示了不同类别的免疫球蛋白在与霍乱弧菌O抗原同时反应中的竞争作用。推测不同免疫球蛋白类别的竞争作用机制在机体的康复（高活性IgM）或解毒（高活性IgG）过程中发挥一定作用。
