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制定优先框架以辅助澳大利亚卫生技术评估中的医疗保健资金决策制定:多准则决策分析的应用。

Development of a Prioritization Framework to Aid Healthcare Funding Decision Making in Health Technology Assessment in Australia: Application of Multicriteria Decision Analysis.

机构信息

Centre for Applied Health Economics, School of Medicine and Dentistry, Griffith University, Nathan, Queensland, Australia.

Department of Health Economics, Wellbeing and Society, Australian National University, Canberra, Australian Capital Territory, Australia.

出版信息

Value Health. 2024 Nov;27(11):1585-1593. doi: 10.1016/j.jval.2024.07.003. Epub 2024 Jul 31.

Abstract

OBJECTIVES

This study develops a prioritization framework to aid healthcare funding decision making in health technology assessment (HTA) in Australia using a multiple criteria decision analysis (MCDA) approach.

METHODS

MCDA frameworks for HTAs were reviewed through literature survey to identify the initial criteria and levels within each criterion. Key stakeholders and experts were consulted to confirm these criteria and levels. A conjoint analysis using 1000Minds was undertaken with policy makers from the Department of Health to establish ranking criteria and weighting scores. Monte Carlo simulations were used to examine the sensitivity of findings to factors affecting the ranking and weighting scores. The MCDA was then applied to 6 examples of chronic care models or technologies projects to demonstrate the performance of this approach.

RESULTS

Five criteria (clinical efficacy/effectiveness, safety and tolerability, severity of the condition, quality/uncertainty, and direct impact on healthcare costs) were consistently ranked highest by healthcare decision makers. Among the criteria, patient-level health outcomes were considered the most important, followed by social and ethical values. The analyses were robust to inform the uncertainty in the parameter.

CONCLUSIONS

This study has developed an MCDA tool that effectively integrates key priorities for HTA reviews, reflecting the values and preferences of healthcare stakeholders in Australia. Although this tool aims to align the assessment process more closely with health benefits, it also highlights the importance of considering other criteria.

摘要

目的

本研究采用多准则决策分析(MCDA)方法,为澳大利亚卫生技术评估(HTA)中的医疗保健资金决策制定开发了一个优先级框架。

方法

通过文献调查回顾了 HTA 的 MCDA 框架,以确定每个标准内的初始标准和级别。咨询了关键利益相关者和专家,以确认这些标准和级别。与卫生部的决策者一起使用 1000Minds 进行了联合分析,以确定排名标准和权重得分。蒙特卡罗模拟用于检查影响排名和权重得分的因素对研究结果的敏感性。然后将 MCDA 应用于 6 个慢性病护理模型或技术项目的示例,以展示该方法的性能。

结果

医疗保健决策者一致将五个标准(临床疗效/有效性、安全性和耐受性、疾病严重程度、质量/不确定性以及对医疗保健成本的直接影响)评为最高。在这些标准中,患者层面的健康结果被认为是最重要的,其次是社会和伦理价值观。分析结果对参数不确定性具有稳健性。

结论

本研究开发了一种 MCDA 工具,有效地整合了 HTA 审查的关键重点,反映了澳大利亚医疗保健利益相关者的价值观和偏好。尽管该工具旨在使评估过程更紧密地与健康效益保持一致,但它也强调了考虑其他标准的重要性。

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