Jiang Zhiwen, Yang Heng, Gao Xinjie, Gao Chao, Jiang Hanqiang, Xu Liquan, Lei Yu, Su Jiabin, Zhang Xin, Gu Yuxiang, Ni Wei
Department of Neurosurgery of Huashan Hospital, State key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science, and Institutes of Brain Science, Fudan University, Shanghai, China.
Department of Neurosurgery of Huashan Hospital, State key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science, and Institutes of Brain Science, Fudan University, Shanghai, China.
World Neurosurg. 2024 Nov;191:e32-e40. doi: 10.1016/j.wneu.2024.07.174. Epub 2024 Aug 2.
Currently, there is no established criterion for determining when interventional treatment is necessary or which strategy is appropriate for basilar artery (BA) aneurysms. Through this study, we aimed to propose an algorithm that can effectively determine the optimal endovascular treatment (EVT) option for BA aneurysms.
We enrolled patients with BA aneurysms from June 2016 to December 2022 and performed procedures based on the algorithm. The analysis included demographic, clinical, and aneurysmal characteristics, procedural details, complications, angiographic outcomes, and clinical outcomes.
This study included 124 patients (mean age 55.0 years) with a BA aneurysm who underwent EVT. Of these, 21 aneurysms were treated in the setting of subarachnoid hemorrhage. The majority of the aneurysms were located at the basilar apex (74), followed by the basilar trunk (30) and vertebrobasilar junction (20). Coiling was used in 18.5% of the cases, while stent-assisted coiling embolization was chosen for 58.9%. Overlapping stents were used in 12.9%, flow diverter implantation in 3.2%, Y/T stent techniques in 4.8%, and stent adjunctive coiling with unilateral vertebral artery occlusion in only 1.6%. Procedure-related complications occurred in 15 patients (12.1%). The patients had a modified Rankin Scale score of 0.74 ± 1.62; 98 (86.7%) had a good prognosis with modified Rankin Scale scores ranging from 0 to 2 at the last follow-up. Digital subtraction angiography was performed on 105 (84.7%) patients, revealing that 101 (81.5%) achieved complete or near-complete occlusion.
The criteria for EVT of BA aneurysms based on multi-characteristics were safe and effective. However, further evidence from large cohort studies is needed.
目前,尚无确定何时需要进行介入治疗或何种策略适用于基底动脉(BA)动脉瘤的既定标准。通过本研究,我们旨在提出一种算法,该算法能够有效地确定BA动脉瘤的最佳血管内治疗(EVT)方案。
我们纳入了2016年6月至2022年12月期间患有BA动脉瘤的患者,并根据该算法进行手术。分析内容包括人口统计学、临床和动脉瘤特征、手术细节、并发症、血管造影结果和临床结果。
本研究纳入了124例接受EVT治疗的BA动脉瘤患者(平均年龄55.0岁)。其中,21例动脉瘤在蛛网膜下腔出血的情况下接受治疗。大多数动脉瘤位于基底动脉顶端(74例),其次是基底动脉主干(30例)和椎基底动脉交界处(20例)。18.5%的病例采用了单纯弹簧圈栓塞,而58.9%的病例选择了支架辅助弹簧圈栓塞。12.9%的病例使用了重叠支架,3.2%的病例植入了血流导向装置,4.8%的病例采用了Y/T型支架技术,仅1.6%的病例采用了支架辅助弹簧圈栓塞并单侧椎动脉闭塞。15例患者(12.1%)发生了与手术相关的并发症。患者的改良Rankin量表评分为0.74±1.62;98例(86.7%)患者在最后一次随访时预后良好,改良Rankin量表评分在0至2分之间。105例(84.7%)患者进行了数字减影血管造影,结果显示101例(81.5%)实现了完全或接近完全闭塞。
基于多特征的BA动脉瘤EVT标准是安全有效的。然而仍需要来自大型队列研究的进一步证据。