James M J, Walsh J A
Thromb Res. 1985 Sep 1;39(5):587-93. doi: 10.1016/0049-3848(85)90238-5.
We have studied interactions between aspirin and alcohol in vitro with regard to their effects on platelet thromboxane synthesis and vascular prostacyclin synthesis. Alcohol did not affect the inhibition by aspirin of platelet thromboxane synthesis. However, low concentrations of alcohol (0.05-0.15%, v/v) reversed the inhibition by aspirin of vascular prostacyclin synthesis. Since the effects on prostacyclin and thromboxane synthesis would favour bleeding rather than haemostasis, the observations reported herein may explain previous reports of a potentiation by alcohol of the aspirin-induced increase in bleeding time.
我们已经在体外研究了阿司匹林与酒精之间的相互作用，涉及它们对血小板血栓素合成和血管前列环素合成的影响。酒精不影响阿司匹林对血小板血栓素合成的抑制作用。然而，低浓度酒精（0.05 - 0.15%，体积/体积）可逆转阿司匹林对血管前列环素合成的抑制作用。由于对前列环素和血栓素合成的影响有利于出血而非止血，本文报道的观察结果可能解释了先前关于酒精增强阿司匹林诱导的出血时间延长的报道。
