Jalal Rezaei, Shahrzad Ghiyasvandian, Roya Azouji, Masoumeh Zakerimoghadam
School of Nursing and Midwifery, Tehran University of Medical Sciences, Tehran, Iran.
Department of Medical-Surgical Nursing, Tehran University of Medical Sciences, Tehran, Iran.
Hematol Transfus Cell Ther. 2024 Dec;46 Suppl 6(Suppl 6):S144-S149. doi: 10.1016/j.htct.2024.02.029. Epub 2024 Apr 17.
Common side effects after stem cell transplantation (SCT), such as anorexia, nausea, and vomiting, can disrupt the quality of life of patients. Therefore, this study aimed to determine the effect of self-care education with smart phone applications on the severity of nausea and vomiting after SCT in leukemia patients.
In this clinical trial study, using the blocked randomization method 104 leukemia patients undergoing SCT were assigned to two groups, intervention and control. The patients of the Control Group received routine care, and the Intervention Group received self-care education with a smart mobile phone application, in addition to routine care. Two weeks, one month, and three months after the start of the intervention, the severity of nausea and vomiting was evaluated using the visual analog scale (VAS) and the Khavar Oncology scale, both of which were completed by both Control and Intervention Groups. Data were analyzed using chi-square, Fisher's exact, Mann-Whitney, and Friedman tests using the Statistical Package for Social Sciences version 25 software.
The severity of nausea and vomiting in leukemia patients undergoing SCT was significantly different in the two groups at all three timepoints (two weeks, one month, and three months) after transplantation (p-value = 0.000).
The severity of nausea and vomiting after SCT in leukemia patients was improved by self-care education with a smart phone application. Therefore, this method is recommended to reduce the severity of nausea and vomiting in leukemia patients who undergo transplantation.
干细胞移植（SCT）后的常见副作用，如厌食、恶心和呕吐，会扰乱患者的生活质量。因此，本研究旨在确定使用智能手机应用程序进行自我护理教育对白血病患者SCT后恶心和呕吐严重程度的影响。
在这项临床试验研究中，采用区组随机化方法将104例接受SCT的白血病患者分为两组，即干预组和对照组。对照组患者接受常规护理，干预组患者除接受常规护理外，还通过一款智能移动应用程序接受自我护理教育。在干预开始后的两周、一个月和三个月，使用视觉模拟量表（VAS）和哈瓦尔肿瘤量表评估恶心和呕吐的严重程度，对照组和干预组均需完成这两个量表。使用社会科学统计软件包第25版软件，通过卡方检验、Fisher精确检验、Mann-Whitney检验和Friedman检验对数据进行分析。
在移植后的所有三个时间点（两周、一个月和三个月），两组接受SCT的白血病患者恶心和呕吐的严重程度均存在显著差异（p值 = 0.000）。
通过智能手机应用程序进行自我护理教育可改善白血病患者SCT后恶心和呕吐的严重程度。因此，建议采用这种方法来减轻接受移植的白血病患者恶心和呕吐的严重程度。
