Department of Pediatrics, Duke University, Durham, NC, USA.
Social, Statistical and Environmental Sciences Unit, RTI International, Research Triangle Park, Durham, NC, USA.
J Perinatol. 2024 Sep;44(9):1300-1306. doi: 10.1038/s41372-024-02074-3. Epub 2024 Aug 3.
Evaluate the association between results of the room air (RA) challenge and death, respiratory morbidity, and neurodevelopmental impairment (NDI) at 2 years' corrected age.
Cohort study of infants born <27 weeks' gestational age who underwent a RA challenge to determine BPD diagnosis at 36 weeks postmenstrual age.
Of 1022 infants eligible for the RA challenge, 554 underwent testing and 223 passed. Test result was not associated with death or serious respiratory morbidities [adjusted relative risk (aRR) 1.01, 95% confidence interval (CI) 0.65-1.56] or death or moderate/severe NDI (aRR 1.06, 95% CI 0.81-1.39) at 2 years.
Results of the RA challenge were not associated with differences in respiratory or neurodevelopmental morbidity at 2 years, suggesting the RA challenge does not add prognostic value in contemporary extremely preterm infants.
Generic Database: NCT00063063.
评估室气（RA）挑战的结果与死亡、呼吸发病率和 2 年校正年龄时的神经发育损伤（NDI）之间的关联。
对胎龄<27 周出生的婴儿进行队列研究，他们在 36 周月经龄时接受 RA 挑战以确定 BPD 诊断。
在 1022 名有资格接受 RA 挑战的婴儿中，有 554 名接受了测试，其中 223 名通过了测试。测试结果与死亡或严重呼吸发病率（调整后的相对风险[aRR]1.01，95%置信区间[CI]0.65-1.56）或 2 年时的死亡或中度/重度 NDI（aRR 1.06，95% CI 0.81-1.39）无关。
RA 挑战的结果与 2 年时呼吸或神经发育发病率的差异无关，这表明 RA 挑战在当代极早产儿中没有增加预后价值。
通用数据库：NCT00063063。
