• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

CYP3A5(c.6986A>G)基因多态性与胱抑素 C 正常的高血压成人肾脏损害的相关性。

Associations Between CYP3A5 (c.6986A>G) Gene Polymorphism and Kidney Impairment in Hypertensive Adults Without Cystatin C Elevation.

机构信息

Department of Endocrinology, The First Affiliated Hospital of Soochow University, Suzhou City, 215000, Jiangsu Province, People's Republic of China.

Department of Cardiology, The Fourth Affiliated Hospital of Soochow University, Suzhou City, 215125, Jiangsu Province, People's Republic of China.

出版信息

Cardiovasc Toxicol. 2024 Oct;24(10):1047-1052. doi: 10.1007/s12012-024-09902-0. Epub 2024 Aug 2.

DOI:10.1007/s12012-024-09902-0
PMID:39095622
Abstract

OBJECTIVE

This study aimed to explore the potential role of CYP3A5 (c. 6986A>G) gene polymorphism in predicting kidney function impairment in patients with hypertension who did not have elevated serum cystatin C.

METHODS

We recruited a group of patients with hypertension who did not have elevated cystatin C and analyzed the CYP3A5 (c. 6986A>G) gene polymorphism. Chi-square tests were used to compare the clinical characteristics and genotypic distribution between the two groups. Logistic regression analysis was used to explore the association between CYP3A5 (c.6986A>G) gene polymorphism and renal function impairment in hypertension with non-elevated cystatin.

RESULTS

In patients with hypertension who participated in the study, there was a significant association between CYP3A5 (c. 6986A>G) gene polymorphism and kidney function impairment (p < 0.05). Patients with the CYP3A5 (c. 6986A>G) mutation display a greater risk of kidney function impairment.

CONCLUSION

CYP3A5 (c. 6986A>G) gene AA homozygote polymorphism significantly increases risk of kidney function impairment in patients with hypertension with normal cystatin C. However, further studies are needed to validate this association and to further understand the mechanism of CYP3A5 (c. 6986A>G) gene polymorphism in kidney function impairment in patients with hypertension.

摘要

目的

本研究旨在探讨 CYP3A5(c.6986A>G) 基因多态性在预测未升高血清胱抑素 C 的高血压患者肾功能损害中的潜在作用。

方法

我们招募了一组未升高胱抑素 C 的高血压患者，并分析了 CYP3A5(c.6986A>G) 基因多态性。卡方检验用于比较两组间的临床特征和基因型分布。Logistic 回归分析用于探讨 CYP3A5(c.6986A>G) 基因多态性与非升高胱抑素的高血压患者肾功能损害之间的关系。

结果

在参加研究的高血压患者中，CYP3A5(c.6986A>G) 基因多态性与肾功能损害之间存在显著关联(p<0.05)。携带 CYP3A5(c.6986A>G) 突变的患者发生肾功能损害的风险更大。

结论

CYP3A5(c.6986A>G) 基因 AA 纯合子多态性显著增加了正常胱抑素 C 的高血压患者肾功能损害的风险。然而，需要进一步的研究来验证这种关联，并进一步了解 CYP3A5(c.6986A>G) 基因多态性在高血压患者肾功能损害中的机制。

相似文献

1
Associations Between CYP3A5 (c.6986A>G) Gene Polymorphism and Kidney Impairment in Hypertensive Adults Without Cystatin C Elevation.CYP3A5(c.6986A>G)基因多态性与胱抑素 C 正常的高血压成人肾脏损害的相关性。
Cardiovasc Toxicol. 2024 Oct;24(10):1047-1052. doi: 10.1007/s12012-024-09902-0. Epub 2024 Aug 2.
2
The potential Role of CYP2D6*10(c.100 C>T) Gene Polymorphism in Kidney Injury of Patients with Hypertension Complicated with Non-Elevated Cystatin C.CYP2D6*10(c.100 C>T) 基因多态性在伴有胱抑素 C 未升高的高血压患者肾损伤中的潜在作用。
Cardiovasc Toxicol. 2024 Aug;24(8):836-841. doi: 10.1007/s12012-024-09880-3. Epub 2024 Jun 12.
3
CYP3A5 as a candidate gene for hypertension: no support from an unselected indigenous West African population.细胞色素P450 3A5作为高血压候选基因：未得到未选择的西非本土人群的支持。
J Hum Hypertens. 2016 Dec;30(12):778-782. doi: 10.1038/jhh.2016.25. Epub 2016 Jun 23.
4
Influence of CYP3A4, CYP3A5 and MDR-1 polymorphisms on tacrolimus pharmacokinetics and early renal dysfunction in liver transplant recipients.CYP3A4、CYP3A5 和 MDR-1 多态性对肝移植受者他克莫司药代动力学和早期肾功能障碍的影响。
Gene. 2013 Jan 10;512(2):226-31. doi: 10.1016/j.gene.2012.10.048. Epub 2012 Oct 26.
5
Association of CYP3A4-392A/G, CYP3A5-6986A/G, and ABCB1-3435C/T Polymorphisms with Tacrolimus Dose, Serum Concentration, and Biochemical Parameters in Mexican Patients with Kidney Transplant.墨西哥肾移植患者中CYP3A4 - 392A/G、CYP3A5 - 6986A/G和ABCB1 - 3435C/T基因多态性与他克莫司剂量、血清浓度及生化参数的相关性
Genes (Basel). 2024 Apr 16;15(4):497. doi: 10.3390/genes15040497.
6
Effect of CYP3A51/3 polymorphism on blood pressure in renal transplant recipients.
Transplant Proc. 2012 Nov;44(9):2596-8. doi: 10.1016/j.transproceed.2012.09.047.
7
Influence of combined CYP3A4 and CYP3A5 single-nucleotide polymorphisms on tacrolimus exposure in kidney transplant recipients: a study according to the post-transplant phase.CYP3A4和CYP3A5单核苷酸多态性联合对肾移植受者他克莫司血药浓度的影响：一项根据移植后阶段的研究。
Pharmacogenomics. 2015 Dec;16(18):2045-54. doi: 10.2217/pgs.15.138. Epub 2015 Nov 30.
8
Correlations of serum cystatin C level and gene polymorphism with vascular cognitive impairment after acute cerebral infarction.血清胱抑素 C 水平与基因多态性与急性脑梗死血管性认知障碍的相关性。
Neurol Sci. 2019 May;40(5):1049-1054. doi: 10.1007/s10072-019-03777-8. Epub 2019 Feb 25.
9
Association of the CYP3A5 polymorphism (6986G>A) with blood pressure and hypertension.CYP3A5 多态性（6986G>A）与血压和高血压的关联。
Hypertens Res. 2011 Nov;34(11):1216-20. doi: 10.1038/hr.2011.112. Epub 2011 Aug 4.
10
Effect of CYP3A and ABCB1 single nucleotide polymorphisms on the pharmacokinetics and pharmacodynamics of calcineurin inhibitors: Part II.CYP3A 和 ABCB1 单核苷酸多态性对钙调神经磷酸酶抑制剂的药代动力学和药效学的影响：第二部分。
Clin Pharmacokinet. 2010 Apr;49(4):207-21. doi: 10.2165/11317550-000000000-00000.

本文引用的文献

1
Statin therapy for patients with diabetic nephropathy: balance between safety and efficacy of statin treatment for patients with impaired kidney function.他汀类药物治疗糖尿病肾病患者：在肾功能受损患者他汀治疗的安全性和疗效之间取得平衡。
Eur Rev Med Pharmacol Sci. 2023 Nov;27(21):10595-10604. doi: 10.26355/eurrev_202311_34339.
2
Midterm eGFR Predicts Pregnancy Outcomes: An Observational Study.中期 eGFR 预测妊娠结局：一项观察性研究。
J Assoc Physicians India. 2022 Dec;70(12):11-12. doi: 10.5005/japi-11001-0164.
3
The Interaction of Gut Microbiota and Heart Failure with Preserved Ejection Fraction: From Mechanism to Potential Therapies.
射血分数保留的心力衰竭与肠道微生物群的相互作用：从机制到潜在治疗方法
Biomedicines. 2023 Feb 2;11(2):442. doi: 10.3390/biomedicines11020442.
4
Cystatin C-Based Equation to Estimate GFR without the Inclusion of Race and Sex.基于胱抑素C的估算肾小球滤过率的公式，不纳入种族和性别因素。
N Engl J Med. 2023 Jan 26;388(4):333-343. doi: 10.1056/NEJMoa2203769.
5
Statin therapy may protect against acute kidney injury in patients hospitalized for interstitial SARS-CoV2 pneumonia.他汀类药物治疗可能有助于预防因间质 SARS-CoV2 肺炎住院的患者发生急性肾损伤。
Nutr Metab Cardiovasc Dis. 2023 Jan;33(1):227-231. doi: 10.1016/j.numecd.2022.10.005. Epub 2022 Oct 18.
6
Serum Cystatin C for Estimation of GFR.用于估算肾小球滤过率的血清胱抑素C
JAMA. 2022 Sep 6;328(9):883-884. doi: 10.1001/jama.2022.12407.
7
Diagnosis and treatment of arterial hypertension 2021.2021 年动脉高血压的诊断与治疗。
Kidney Int. 2022 Jan;101(1):36-46. doi: 10.1016/j.kint.2021.09.026. Epub 2021 Oct 29.
8
Cystatin C and arterial stiffness in patients without chronic kidney disease.胱抑素 C 与无慢性肾脏病患者的动脉僵硬度。
Clin Nephrol. 2021;96(1):43-48. doi: 10.5414/CNP96S08.
9
New Creatinine- and Cystatin C-Based Equations to Estimate GFR without Race.新型基于肌酐和胱抑素 C 的估算肾小球滤过率方程，无需考虑种族因素。
N Engl J Med. 2021 Nov 4;385(19):1737-1749. doi: 10.1056/NEJMoa2102953. Epub 2021 Sep 23.
10
Renal metabolism and hypertension.肾脏代谢与高血压。
Nat Commun. 2021 Feb 11;12(1):963. doi: 10.1038/s41467-021-21301-5.