Mattos Matheus Silvério, Vandendriessche Sofie, Waisman Ari, Marques Pedro Elias
Laboratory of Molecular Immunology, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, 3000, Louvain, Belgium.
Institute for Molecular Medicine, University Medical Centre of the Johannes Gutenberg University of Mainz, Mainz, Germany.
Immun Ageing. 2024 Aug 2;21(1):54. doi: 10.1186/s12979-024-00455-y.
B-1 cells have intricate biology, with distinct function, phenotype and developmental origin from conventional B cells. They generate a B cell receptor with conserved germline characteristics and biased V(D)J recombination, allowing this innate-like lymphocyte to spontaneously produce self-reactive natural antibodies (NAbs) and become activated by immune stimuli in a T cell-independent manner. NAbs were suggested as "rheostats" for the chronic diseases in advanced age. In fact, age-dependent loss of function of NAbs has been associated with clinically-relevant diseases in the elderly, such as atherosclerosis and neurodegenerative disorders. Here, we analyzed comprehensively the ontogeny, phenotypic characteristics, functional properties and emerging roles of B-1 cells and NAbs in health and disease. Additionally, after navigating through the complexities of B-1 cell biology from development to aging, therapeutic opportunities in the field are discussed.
B-1细胞具有复杂的生物学特性，其功能、表型和发育起源与传统B细胞不同。它们产生具有保守种系特征和偏向性V(D)J重组的B细胞受体，使这种先天样淋巴细胞能够自发产生自身反应性天然抗体（NAb），并以不依赖T细胞的方式被免疫刺激激活。NAb被认为是老年慢性疾病的“调节器”。事实上，NAb功能的年龄依赖性丧失与老年人的临床相关疾病有关，如动脉粥样硬化和神经退行性疾病。在这里，我们全面分析了B-1细胞和NAb在健康和疾病中的个体发生、表型特征、功能特性及新出现的作用。此外，在梳理了从发育到衰老的B-1细胞生物学复杂性之后，还讨论了该领域的治疗机会。
