Department of Molecular Biosciences and the LaMontagne Center for Infectious Diseases, The University of Texas at Austin, Austin, Texas, USA.
Mol Microbiol. 2024 Oct;122(4):447-454. doi: 10.1111/mmi.15301. Epub 2024 Aug 3.
FliL is a bacterial flagellar protein demonstrated to associate with, and regulate ion flow through, the stator complex in a diverse array of bacterial species. FliL is also implicated in additional functions such as stabilizing the flagellar rod, modulating rotor bias, sensing the surface, and regulating gene expression. How can one protein do so many things? Its location is paramount to understanding its numerous functions. This review will look at the evidence, attempt to resolve some conflicting findings, and offer new thoughts on FliL.
FliL 是一种细菌鞭毛蛋白，已被证明可与各种细菌的定子复合物结合并调节离子流。FliL 还涉及其他功能，例如稳定鞭毛杆、调节转子偏置、感应表面和调节基因表达。一种蛋白质怎么能有这么多功能？它的位置对于理解其众多功能至关重要。这篇综述将探讨证据，尝试解决一些相互矛盾的发现，并对 FliL 提出新的思考。
