Stewart Hamish, Petzoldt Johannes, Shanley Toby, Grinfeld Dmitry, Denisov Eduard, Hagedorn Bernd, Dwivedi Ankit, Mourad Daniel, Ostermann Robert, Ochmann Maximilian, Cochems Philipp, Wagner Alexander, Balschun Wilko, Makarov Alexander, Shofman Semyon, Moti Ben-David, Weingarten Amit, Kadyshevitch Sasha, Hock Christian
Thermo Fisher Scientific, 11 Hannah-Kunath Strasse, 28199 Bremen, Germany.
El-Mul Technologies Ltd., 12 Hamada Street, Rehovot, 7670315 Israel.
J Am Soc Mass Spectrom. 2024 Oct 2;35(10):2390-2399. doi: 10.1021/jasms.4c00230. Epub 2024 Aug 3.
Reflectron-based time-of-flight analyzers rely on subnanosecond detector time response to achieve acceptable resolving power for low-mid-mass, multiple-ion peaks. With the adoption of multireflection analyzers, order of magnitude longer folded ion paths relax restrictions on detector response time, allowing implementation of new technologies that greatly improve dynamic range, detector lifetime, and ion detection efficiency. A detection system is presented, integrated into a multireflection analyzer, that combines 10 keV postacceleration and focal plane correction with a unique BxE focusing, optically coupled detector, preamplification, and dual-channel digitization. Calibration and peak-handling methods are also described. The instrument demonstrated >1 × 10 dynamic range in a single shot, > 100k resolving power, and a relative immunity to detector aging.
基于反射电子的飞行时间分析仪依靠亚纳秒级的探测器时间响应,来实现对低中质量多离子峰可接受的分辨能力。随着多反射分析仪的采用,数量级更长的折叠离子路径放宽了对探测器响应时间的限制,从而能够采用新技术,极大地提高动态范围、探测器寿命和离子检测效率。本文介绍了一种集成在多反射分析仪中的检测系统,该系统将10 keV的后加速和焦平面校正与独特的BxE聚焦、光耦合探测器、前置放大和双通道数字化相结合。还描述了校准和峰处理方法。该仪器单次测量展示出大于1×10的动态范围、大于100k的分辨能力以及对探测器老化的相对抗性。