Key Laboratory of Cognition and Personality of the Ministry of Education, Southwest University, 2 Tiansheng Rd., Beibei District, Chongqing 400715, China.
Soc Cogn Affect Neurosci. 2024 Aug 1;19(1). doi: 10.1093/scan/nsae052.
Recent studies using resting-state functional magnetic resonance imaging have shown that loneliness is associated with altered blood oxygenation in several brain regions. However, the relationship between loneliness and changes in neuronal rhythm activity in the brain remains unclear. To evaluate brain rhythm, we conducted an exploratory resting-state electroencephalogram (EEG) study of loneliness. We recorded resting-state EEG signals from 139 participants (94 women; mean age = 19.96 years) and analyzed power spectrum density (PSD) and functional connectivity (FC) in both the electrode and source spaces. The PSD analysis revealed significant correlations between loneliness scores and decreased beta-band powers, which may indicate negative emotion, attention, reward, and/or sensorimotor processing. The FC analysis revealed a trend of alpha-band FC associated with individuals' loneliness scores. These findings provide new insights into the neural basis of loneliness, which will facilitate the development of neurobiologically informed interventions for loneliness.
最近利用静息态功能磁共振成像的研究表明，孤独感与大脑几个区域的血氧变化有关。然而，孤独感与大脑中神经元节律活动变化之间的关系尚不清楚。为了评估脑节律，我们对孤独感进行了一项探索性的静息态脑电图（EEG）研究。我们记录了 139 名参与者（94 名女性；平均年龄 19.96 岁）的静息态 EEG 信号，并在电极和源空间中分析了功率谱密度（PSD）和功能连接（FC）。PSD 分析显示，孤独评分与β波段功率降低呈显著相关，这可能表明存在消极情绪、注意力、奖励和/或感觉运动处理。FC 分析显示，与个体孤独评分相关的α波段 FC 呈趋势性。这些发现为孤独感的神经基础提供了新的见解，这将有助于开发孤独感的神经生物学干预措施。
