Groningen Institute for Evolutionary Life Sciences (GELIFES), Neurobiology, University of Groningen, Nijenborgh 7, Groningen 9747 AG, the Netherlands.
Groningen Institute for Evolutionary Life Sciences (GELIFES), Neurobiology, University of Groningen, Nijenborgh 7, Groningen 9747 AG, the Netherlands.
Neurosci Biobehav Rev. 2024 Sep;164:105839. doi: 10.1016/j.neubiorev.2024.105839. Epub 2024 Aug 2.
Our intricate social brain is implicated in a range of brain disorders, where social dysfunction emerges as a common neuropsychiatric feature cutting across diagnostic boundaries. Understanding the neurocircuitry underlying social dysfunction and exploring avenues for its restoration could present a transformative and transdiagnostic approach to overcoming therapeutic challenges in these disorders. The brain's default mode network (DMN) plays a crucial role in social functioning and is implicated in various neuropsychiatric conditions. By thoroughly examining the current understanding of DMN functionality, we propose that the DMN integrates diverse social processes, and disruptions in brain communication at regional and network levels due to disease hinder the seamless integration of these social functionalities. Consequently, this leads to an altered balance between self-referential and attentional processes, alongside a compromised ability to adapt to social contexts and anticipate future social interactions. Looking ahead, we explore how adopting an integrated neurocircuitry perspective on social dysfunction could pave the way for innovative therapeutic approaches to address brain disorders.
我们复杂的社交大脑与一系列大脑紊乱有关，其中社交功能障碍是一种常见的神经精神特征，贯穿于各种诊断界限。了解社交功能障碍的神经回路，并探索恢复其功能的途径，可能为克服这些疾病的治疗挑战提供一种变革性的、跨诊断的方法。大脑的默认模式网络（DMN）在社交功能中起着关键作用，并与各种神经精神疾病有关。通过深入研究 DMN 功能的现有理解，我们提出 DMN 整合了各种社交过程，而由于疾病导致的大脑在区域和网络层面的通讯中断会阻碍这些社交功能的无缝整合。因此，这会导致自我参照和注意力过程之间的平衡被改变，以及适应社交环境和预测未来社交互动的能力受损。展望未来，我们探讨了采用社交功能障碍的综合神经回路观点如何为解决大脑紊乱的创新治疗方法铺平道路。
