College of Chemistry and Chemical Engineering, Anyang Normal University, Anyang, Henan 455000, China; Department of Chemistry, Clemson University, Clemson, SC 29634, United States.
College of Chemistry and Chemical Engineering, Anyang Normal University, Anyang, Henan 455000, China.
Ecotoxicol Environ Saf. 2024 Sep 1;282:116836. doi: 10.1016/j.ecoenv.2024.116836. Epub 2024 Aug 3.
Since the onset of the SARS-CoV-2 pandemic in early 2020, there has been a notable rise in sodium hypochlorite disinfectants. Sodium hypochlorite undergoes hydrolysis to generate hypochlorous acid for virus eradication. This chlorine-based disinfectant is widely utilized for public disinfection due to its effectiveness. Although sodium hypochlorite disinfection is convenient, its excessive and indiscriminate use can harm the water environment and pose a risk to human health. Hypochlorous acid, a reactive oxygen species, plays a crucial role in the troposphere, stratospheric chemistry, and oxidizing capacity. Additionally, hypochlorous acid is vital as a reactive oxygen species in biological systems, and its irregular metabolism and level is associated with several illnesses. Thus, it is crucial to identify hypochlorous acid to comprehend its environmental and biological functions precisely. Here, we constructed a new fluorescent probe, utilizing the twisted intramolecular charge transfer mechanism to quickly and accurately detect hypochlorous acid in environmental water and biosystems. The probe showed a notable increase in fluorescence when exposed to hypochlorous acid, demonstrating its excellent selectivity, fast response time (less than 10 seconds), a large Stokes shift (∼ 102 nm), and a low detection limit of 15.5 nM.
自 2020 年初 SARS-CoV-2 大流行以来，次氯酸钠消毒剂的使用显著增加。次氯酸钠会发生水解，生成次氯酸以消灭病毒。由于其高效性，这种含氯消毒剂被广泛用于公共消毒。尽管次氯酸钠消毒方便，但过度和无差别使用会对水环境造成危害，对人体健康构成威胁。次氯酸作为一种活性氧物质，在对流层、平流层化学和氧化能力中发挥着重要作用。此外，次氯酸在生物系统中作为一种活性氧物质至关重要，其代谢和水平的异常与多种疾病有关。因此，准确识别次氯酸对于精确了解其环境和生物学功能至关重要。在这里，我们构建了一种新的荧光探针，利用扭曲的分子内电荷转移机制，快速准确地检测环境水和生物系统中的次氯酸。当探针暴露于次氯酸时，荧光显著增强，表现出优异的选择性、快速的响应时间（小于 10 秒）、较大的斯托克斯位移（~102nm）和低检测限为 15.5nM。
