Centre for Eye and Vision Research (CEVR), 17W Hong Kong Science Park, Hong Kong.
Centre for Eye and Vision Research (CEVR), 17W Hong Kong Science Park, Hong Kong; Centre for Myopia Research, School of Optometry, The Hong Kong Polytechnic University, Hong Kong.
Cont Lens Anterior Eye. 2024 Dec;47(6):102281. doi: 10.1016/j.clae.2024.102281. Epub 2024 Aug 2.
To evaluate the repeatability and agreement in dry eye measurements using Oculus Keratograph 5M (K5M) and SBM Sistemi IDRA (IDRA).
A total of 108 participants were enrolled and 108 eyes were evaluated. Tear meniscus height (TMH) and first and average non-invasive break-up time (NIBUT) were measured using the K5M and IDRA (order randomly assigned). TMH was measured using the built-in caliper tool while NIBUT was computed by the automatic algorithm of the instruments.
The Bland Altman plots analysis showed a good agreement between the two instruments for TMH (95 % Limits of Agreement (LoA), -0.17 to 0.16), but not the first NIBUT (95 % LoA, -8.13 to 14.79) and average NIBUT (95 % LoA, -7.89 to 10.32). The values of the first and average NIBUT measured using IDRA were significantly shorter than in K5M (difference = median (IQR) -2.75 (-6.48- -0.28)s, p < 0.001 and difference = median (IQR) -1.65 (-3.97-1.89)s, p = 0.008 respectively). The TMH (p = 0.037) and NIBUT average (p = 0.033) measured by K5M, as well as the TMH (p = 0.040) measured by IDRA, exhibited unstable measurements across the three measurement times. The remaining parameters exhibited stability with three repeated measurements.
The NIBUT measurements are not interchangeable between IDRA and K5M, while the TMH was little difference between the two instruments. It is important to exercise caution when using different ocular surface analyzers to minimize errors in comparing multiple measurements.
评估使用 Oculus Keratograph 5M（K5M）和 SBM Sistemi IDRA（IDRA）进行干眼测量的重复性和一致性。
共纳入 108 名参与者，共评估 108 只眼。使用 K5M 和 IDRA（随机分配顺序）测量泪膜弯曲度（TMH）和首次及平均非侵入性泪膜破裂时间（NIBUT）。使用内置卡尺工具测量 TMH，而 NIBUT 则由仪器的自动算法计算。
Bland Altman 图分析显示两种仪器测量 TMH 的一致性较好（95%一致性界限（LoA），-0.17 至 0.16），但首次 NIBUT（95% LoA，-8.13 至 14.79）和平均 NIBUT（95% LoA，-7.89 至 10.32）的一致性较差。使用 IDRA 测量的首次和平均 NIBUT 值明显短于 K5M（差异=中位数（IQR）-2.75（-6.48-0.28）s，p<0.001 和差异=中位数（IQR）-1.65（-3.97-1.89）s，p=0.008）。K5M 测量的 TMH（p=0.037）和平均 NIBUT（p=0.033）以及 IDRA 测量的 TMH（p=0.040）在三个测量时间点的测量值均不稳定。其余参数在三次重复测量中表现出稳定性。
IDRA 和 K5M 之间的 NIBUT 测量值不可互换，而两种仪器之间的 TMH 差异较小。使用不同的眼表面分析仪时，应谨慎操作，以最大程度地减少比较多次测量时的误差。
