Landmark K, Dale J
Acta Med Scand. 1985;218(4):389-96. doi: 10.1111/j.0954-6820.1985.tb08863.x.
In a double-blind, cross-over study for 8 weeks, including 10 non-hospitalized elderly hypertensives (average age 73.2 years), WHO stage I-II, the antihypertensive effect of nifedipine slow-release tablets, 20 mg twice daily, was compared with placebo. Nifedipine reduced supine and standing blood pressure values significantly, and no signs of orthostatic hypotension were noted. An initial increment in heart rate was found after 1 week with a subsequent fall towards control values after 8 weeks of nifedipine administration. Heart rate pressure product in the supine position was reduced, and this reduction became statistically significant at the 8th week. Cardiac output measured non-invasively in 8 patients after 6-8 weeks' nifedipine therapy, using an Irex echocardiograph, was on an average 34% higher than in the placebo period (p less than 0.05). Serum electrolytes, cholesterol, HDL cholesterol, blood glucose and renal function were not affected by the drug. Side-effects were few and mild. It is concluded that nifedipine is a potent antihypertensive agent which may represent an attractive first choice alternative in the treatment of elderly hypertensive patients.
在一项为期8周的双盲交叉研究中，纳入了10名非住院老年高血压患者（平均年龄73.2岁），WHO分级为I-II期，将每日两次、每次20毫克硝苯地平缓释片的降压效果与安慰剂进行了比较。硝苯地平显著降低了仰卧位和站立位血压值，未观察到直立性低血压的迹象。服用硝苯地平1周后心率出现初始升高，随后在给药8周后降至对照值。仰卧位心率血压乘积降低，且在第8周时这种降低具有统计学意义。使用Irex超声心动图对8例患者在接受6-8周硝苯地平治疗后进行无创心输出量测量，平均比安慰剂治疗期高出34%（p<0.05）。血清电解质、胆固醇、高密度脂蛋白胆固醇、血糖和肾功能均未受该药物影响。副作用少且轻微。结论是，硝苯地平是一种有效的降压药物，可能是治疗老年高血压患者有吸引力的首选药物。
