尼索地平在老年和年轻受试者中的药代动力学比较。
A comparison of the pharmacokinetics of nisoldipine in elderly and young subjects.
作者信息
Baksi A K, Edwards J S, Ahr G
机构信息
St Mary's Hospital, Newport, Isle of Wight.
出版信息
Br J Clin Pharmacol. 1991 Mar;31(3):367-70. doi: 10.1111/j.1365-2125.1991.tb05547.x.
Abstract
Nine young and 12 elderly healthy volunteers received nisoldipine 10 mg once a day for 7 days. Plasma nisoldipine concentrations were measured on Day 1 and on Day 7. Higher plasma drug concentrations were observed in the elderly group than in the young group with the values for AUC being approximately doubled in the elderly group. There was no evidence of significant accumulation in either age group.
摘要
9名年轻健康志愿者和12名老年健康志愿者每天服用一次10毫克尼索地平，共服用7天。在第1天和第7天测量血浆尼索地平浓度。老年组的血浆药物浓度高于年轻组，老年组的AUC值约为年轻组的两倍。在两个年龄组中均未发现明显的药物蓄积迹象。
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