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尼索地平在老年和年轻受试者中的药代动力学比较。

A comparison of the pharmacokinetics of nisoldipine in elderly and young subjects.

作者信息

Baksi A K, Edwards J S, Ahr G

机构信息

St Mary's Hospital, Newport, Isle of Wight.

出版信息

Br J Clin Pharmacol. 1991 Mar;31(3):367-70. doi: 10.1111/j.1365-2125.1991.tb05547.x.

DOI:10.1111/j.1365-2125.1991.tb05547.x
PMID:2054280
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1368370/
Abstract

Nine young and 12 elderly healthy volunteers received nisoldipine 10 mg once a day for 7 days. Plasma nisoldipine concentrations were measured on Day 1 and on Day 7. Higher plasma drug concentrations were observed in the elderly group than in the young group with the values for AUC being approximately doubled in the elderly group. There was no evidence of significant accumulation in either age group.

摘要

9名年轻健康志愿者和12名老年健康志愿者每天服用一次10毫克尼索地平，共服用7天。在第1天和第7天测量血浆尼索地平浓度。老年组的血浆药物浓度高于年轻组，老年组的AUC值约为年轻组的两倍。在两个年龄组中均未发现明显的药物蓄积迹象。

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本文引用的文献

1
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Acta Med Scand. 1985;218(4):389-96. doi: 10.1111/j.0954-6820.1985.tb08863.x.
2
Age-related changes in the pharmacokinetics and pharmacodynamics of nifedipine.硝苯地平药代动力学和药效学的年龄相关性变化。
Br J Clin Pharmacol. 1988 Mar;25(3):297-305. doi: 10.1111/j.1365-2125.1988.tb03307.x.
3
Plasma nitrendipine concentrations in elderly hypertensive patients after single and multiple dosing.老年高血压患者单次及多次给药后血浆尼群地平浓度
Br J Clin Pharmacol. 1988 Sep;26(3):323-6. doi: 10.1111/j.1365-2125.1988.tb05283.x.