Perlmutter D, Vacanti J, Donahoe P, Kleinman R
Adv Pediatr. 1985;32:177-96.
Since the introduction of cyclosporine and a multidisciplinary surgical/medical approach, survival has improved in children undergoing orthotopic liver transplantation. In many areas, liver replacement is being considered a genuine treatment option for progressive liver disease. Before this procedure is routinely accepted, however, it will be important to follow long-term outcome and to compare results with those of conventional treatment when there are more patients in each disease category. In addition to continued experimentation with immunosuppressive regimens, methods for monitoring immunosuppression and detecting rejection at early stages are needed. Finally, the changes in bodily processes accompanying liver replacement should be used to learn more about the function of the liver, its role in immunity and its pathobiologic involvement by specific disorders.
自从引入环孢素以及采用多学科手术/内科治疗方法以来，接受原位肝移植的儿童的生存率有所提高。在许多地区，肝脏置换正被视为进行性肝病的一种切实可行的治疗选择。然而，在这种手术被常规接受之前，跟踪长期结果并将结果与每种疾病类别中有更多患者时的传统治疗结果进行比较将非常重要。除了继续试验免疫抑制方案外，还需要监测免疫抑制和早期检测排斥反应的方法。最后，肝脏置换伴随的身体过程变化应用于更多地了解肝脏的功能、其在免疫中的作用以及特定疾病对其病理生物学的影响。
