Zhong Hao, Hussain Muhammad, Hussain Kifayat, Wang Lingmiao, Qayum Abdul, S Hamed Yahya, Guan Rongfa
College of Food Science and Technology, Zhejiang University of Technology, Hangzhou, China.
Moganshan Institute ZJUT, Kangqian District, Deqing, China.
Crit Rev Food Sci Nutr. 2024 Aug 3:1-18. doi: 10.1080/10408398.2024.2384646.
Cyanidin-3-O-glucoside (C3G), is an anthocyanin mainly found in berries, and can also be produced by microorganisms. It has been traditionally used as a natural coloring agent for decades. Recently, it has been investigated for its high antioxidant activity and anti-cancer attributes. C3G has low bioavailability and is sensitive to oxidation and gastric pH; therefore, it is encapsulated in nanoliposomes to enhance its bio-availability, targeted delivery- and efficacy against chronic disease.
In this review, the role of C3G nanoliposomes against major chronic diseases has been discussed. The focus was on research findings and the mechanism of action to affect the proliferation of cancer, neuro disease and cardiovascular problems. It also discussed the formulation of nanoliposomes, their role in nutraceutical delivery and enhancement in C3G bioavailability.
Data suggested that nanoliposomes safeguard C3G, enhance bioavailability, and ensure safe, adequate and targeted delivery. It can reduce the impact of cancer and inflammation by inhibiting the ß-catenin/O6-methylguanine-DNA methyltransferase (MGMT) pathway and upregulating miR-214-5p. Formation of C3G nanoliposomes significantly enhances the nutraceutical efficacy of C3G against major chronic disease therefore, C3G nanoliposomes might be a future-based nutraceutical to treat major chronic diseases, including cancer, neuro problems and CVD, but challenges remain in finding correct dose and techniques to maximize its efficacy.
矢车菊素 - 3 - O - 葡萄糖苷（C3G）是一种主要存在于浆果中的花青素，也可由微生物产生。几十年来，它一直被传统地用作天然色素。最近，人们对其高抗氧化活性和抗癌特性进行了研究。C3G的生物利用度低，对氧化和胃内pH值敏感；因此，它被包裹在纳米脂质体中以提高其生物利用度、靶向递送能力以及对慢性病的疗效。
在本综述中，讨论了C3G纳米脂质体对主要慢性病的作用。重点是关于影响癌症、神经疾病和心血管问题增殖的研究结果及作用机制。还讨论了纳米脂质体的配方、它们在营养保健品递送中的作用以及C3G生物利用度的提高。
数据表明，纳米脂质体可保护C3G，提高生物利用度，并确保安全、充足和靶向递送。它可以通过抑制β - 连环蛋白/O6 - 甲基鸟嘌呤 - DNA甲基转移酶（MGMT）途径和上调miR - 214 - 5p来降低癌症和炎症的影响。C3G纳米脂质体的形成显著提高了C3G对主要慢性病的营养保健功效。因此，C3G纳米脂质体可能是一种未来用于治疗包括癌症、神经问题和心血管疾病在内的主要慢性病的营养保健品，但在找到正确的剂量和技术以最大化其疗效方面仍存在挑战。
