Department of Respiratory Medicine, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam, Tamil Nadu, India.
Faculty of Allied Health Sciences, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam, Tamil Nadu, India.
Ann Med. 2024 Dec;56(1):2386030. doi: 10.1080/07853890.2024.2386030. Epub 2024 Aug 3.
Tuberculosis (TB) continues to pose a significant health challenge worldwide, emphasizing the importance of prompt diagnosis and efficient monitoring of treatment outcomes for effective disease control. Biomarkers have become increasingly important in the realm of TB diagnoses and treatment. The objective of this comprehensive review is to examine the present state of biomarkers employed in the diagnosis of TB, monitoring the response to treatment, and predicting treatment outcomes. In this study, we undertake a comprehensive examination of the diverse biomarkers utilized in TB diagnoses, spanning molecular, immunological, and other novel methodologies. Furthermore, we examine the potential of biomarkers in the context of therapeutic monitoring, assessment of treatment effectiveness, and anticipation of drug resistance. Additionally, this paper presents future prospects regarding the utilization of biomarkers in the therapy of tuberculosis.
结核病（TB）仍然是全球范围内的重大健康挑战，强调了及时诊断和有效监测治疗结果对于有效控制疾病的重要性。生物标志物在结核病的诊断和治疗中变得越来越重要。本综述的目的是检查用于诊断结核病、监测治疗反应和预测治疗结果的生物标志物的现状。在这项研究中，我们全面检查了用于结核病诊断的各种生物标志物，包括分子、免疫和其他新方法。此外，我们还研究了生物标志物在治疗监测、治疗效果评估和耐药性预测方面的潜力。此外，本文还介绍了生物标志物在结核病治疗中的未来应用前景。
