Department for Health, University of Bath, Claverton Down, Bath, UK.
Centre for Nutrition, Exercise & Metabolism, University of Bath, Claverton Down, Bath, UK.
J Physiol. 2024 Sep;602(17):4157-4170. doi: 10.1113/JP286395. Epub 2024 Aug 4.
The effect of acute exercise on circulating concentrations of vitamin D metabolites is unclear. To address this knowledge gap, we examined the effect of a bout of treadmill-based exercise versus rest on circulating concentrations of 25(OH)D, 25(OH)D, 3-epi-25(OH)D, 24,25(OH)D, 1,25(OH)D, and vitamin D and D in healthy men and women. Thirty-three healthy adults (14 females, 41 (15) years, body mass index 26.2 (3.7) kg/m, 36.2 (9.2) ml/kg/min; mean (SD)) completed two laboratory visits involving 60 min of moderate-intensity treadmill exercise (60% ) versus 60 min of seated rest, both in an overnight fasted-state, as part of a randomised crossover design. Venous blood samples were drawn at baseline, immediately (0 h), 1 h and 24 h after the exercise or rest-period. There was a significant time × trial interaction effect for total circulating 25(OH)D (P = 0.0148), 25(OH)D (P = 0.0127) and 1,25(OH)D (P = 0.0226). Immediately post-exercise, 25(OH)D, 25(OH)D and 1,25(OH)D concentrations were significantly elevated compared to the control resting condition, and 1,25(OH) D remained significantly elevated 1 h later. Circulating albumin, vitamin D binding protein, calcium and parathyroid hormone were elevated immediately post-exercise. Thus, an acute bout of moderate intensity exercise transiently increases concentrations of circulating 25(OH)D and 1,25(OH)D compared to resting conditions. KEY POINTS: Observational studies suggest that acute exercise might change circulating concentrations of vitamin D metabolites, but this has not been investigated using randomised crossover studies and using robust analytical procedures. In this study, we used a randomised crossover design to examine the effect of a bout of treadmill-based exercise (vs. rest) on circulating concentrations of a wide range of vitamin D metabolites in healthy humans. We show that an acute bout of moderate intensity exercise transiently increases concentrations of circulating 25(OH)D and 1,25(OH)D compared to resting conditions. These findings indicate that regular exercise could lead to transient but regular windows of enhanced vitamin D biological action.
急性运动对循环维生素 D 代谢物浓度的影响尚不清楚。为了解决这一知识空白，我们研究了一次跑步机运动与休息对健康男性和女性循环 25(OH)D、25(OH)D、3-epi-25(OH)D、24,25(OH)D、1,25(OH)D 和维生素 D 和 D 浓度的影响。33 名健康成年人（14 名女性，41(15)岁，体重指数 26.2(3.7)kg/m，36.2(9.2)ml/kg/min；平均值（SD））完成了两次实验室访问，包括 60 分钟的中等强度跑步机运动（60%）与 60 分钟的坐姿休息，均在禁食过夜状态下进行，作为随机交叉设计的一部分。静脉血样在基线、运动或休息期后 0 小时、1 小时和 24 小时采集。总循环 25(OH)D（P=0.0148）、25(OH)D（P=0.0127）和 1,25(OH)D（P=0.0226）存在显著的时间×试验交互作用。运动后即刻，25(OH)D、25(OH)D 和 1,25(OH)D 浓度明显高于对照静息状态，1 小时后 1,25(OH)D 仍明显升高。运动后即刻，循环白蛋白、维生素 D 结合蛋白、钙和甲状旁腺激素升高。因此，与静息状态相比，一次中等强度的急性运动短暂增加了循环 25(OH)D 和 1,25(OH)D 的浓度。关键要点：观察性研究表明，急性运动可能会改变维生素 D 代谢物的循环浓度，但这尚未通过随机交叉研究和使用稳健的分析程序进行研究。在这项研究中，我们使用随机交叉设计研究了跑步机运动（与休息相比）对健康人循环中广泛的维生素 D 代谢物浓度的影响。我们表明，与静息状态相比，一次急性中等强度运动短暂增加了循环 25(OH)D 和 1,25(OH)D 的浓度。这些发现表明，有规律的运动可能导致短暂但有规律的维生素 D 生物学作用增强窗口。
