Department of Sport, Faculty of Physical Education, Kazimierz Wielki University, 85-091 Bydgoszcz, Poland.
Masdiag Sp. z o.o. Company, 01-882 Warsaw, Poland.
Nutrients. 2021 Jun 8;13(6):1963. doi: 10.3390/nu13061963.
Vitamin D plays pleiotropic roles in the body and hence, changes in its metabolism and distribution during starvation could play an important role in the adaptive response to famine. We aimed to identify the responses of some vitamin D metabolites to 8 d of fasting and exercise.
A repeated-measures design was implemented, in which 14 male volunteers fasted for 8 d and performed an exercise test before and after fasting. Serum samples were collected on day 1 after night fasting and after 8 d of complete food restriction, before and 1 h and 3 h after exercise.
After 8 d of fasting, compared with baseline values, serum 24,25(OH)D and 3--25(OH)D levels significantly increased; those of 25(OH)D and 1,25(OH)D were unaffected; and those of 25(OH)D decreased. Exercise on the first day of fasting induced an increase in serum 3--25(OH)D levels, while exercise performed after 8 d of fasting induced an increase in 25(OH)D, 24,25(OH)D, 25(OH)D, and 3--25(OH)D levels.
Increases in 24,25(OH)D and 3--25(OH)D levels imply that fasting stimulates vitamin D metabolism. The effects of exercise on serum vitamin D metabolites, which are most pronounced after fasting and in subjects with serum 25(OH)D above 25 ng/mL, support the notion that fasting and exercise augment vitamin D metabolism.
维生素 D 在体内发挥多种作用，因此，饥饿期间其代谢和分布的变化可能在对饥荒的适应反应中发挥重要作用。我们旨在确定一些维生素 D 代谢物对 8 天禁食和运动的反应。
采用重复测量设计，14 名男性志愿者禁食 8 天，并在禁食前后进行运动测试。在夜间禁食后第 1 天和完全禁食 8 天后采集血清样本，在运动前、运动后 1 小时和 3 小时采集。
与基线值相比，禁食 8 天后血清 24,25（OH）D 和 3--25（OH）D 水平显著升高；25（OH）D 和 1,25（OH）D 水平不受影响；25（OH）D 水平降低。禁食第 1 天运动可引起血清 3--25（OH）D 水平升高，而禁食 8 天后运动可引起 25（OH）D、24,25（OH）D、25（OH）D 和 3--25（OH）D 水平升高。
24,25（OH）D 和 3--25（OH）D 水平升高表明禁食刺激维生素 D 代谢。运动对血清维生素 D 代谢物的影响在禁食后和血清 25（OH）D 水平高于 25ng/ml 的受试者中最为明显，这支持了禁食和运动增强维生素 D 代谢的观点。
