Alkerata Ali, Al-Janabi Moatasem Hussein, Ahmad Youssef Issa, Jbeili Sohair Salim, Ahmad Issa Y
AL Andalus Private University for Medical Sciences, Faculty of Medicine, Syria.
Department of Pathology, Cancer Research Center, Tishreen University Hospital, Lattakia, Syria.
Int J Surg Case Rep. 2024 Sep;122:110120. doi: 10.1016/j.ijscr.2024.110120. Epub 2024 Aug 3.
Primary breast lymphoma (PBL) is an extremely rare neoplasm, accounting for less than 1 % of breast malignancies and less than 2 % of extranodal non-Hodgkin lymphomas (NHLs).
This case report discusses a 60-year-old female patient presenting with a primary breast lymphoma, specifically diffuse large B-cell lymphoma. The patient had no personal history of breast cancer but exhibited a painless, palpable mass in the left breast with axillary lymphadenopathy.
Diagnostic challenges in distinguishing PBL from primary breast carcinoma are addressed, emphasizing the importance of considering PBL in cases of rapidly enlarging breast masses. Radiological examinations, including mammography and ultrasound, play a crucial role in diagnosis, and excisional biopsy with immunohistochemical staining is essential for accurate histopathological subcategorization.
The presented case underscores the rarity of PBL in the Middle East and highlights the diagnostic and classification challenges, emphasizing the central role of accurate techniques in guiding treatment decisions.
原发性乳腺淋巴瘤(PBL)是一种极其罕见的肿瘤,占乳腺恶性肿瘤的比例不到1%,占结外非霍奇金淋巴瘤(NHL)的比例不到2%。
本病例报告讨论了一名60岁的女性原发性乳腺淋巴瘤患者,具体为弥漫性大B细胞淋巴瘤。该患者无乳腺癌个人史,但左乳出现无痛、可触及的肿块,并伴有腋窝淋巴结肿大。
阐述了区分PBL与原发性乳腺癌的诊断挑战,强调在乳腺肿块迅速增大的病例中考虑PBL的重要性。包括乳腺X线摄影和超声在内的放射学检查在诊断中起关键作用,切除活检及免疫组化染色对于准确的组织病理学分类至关重要。
该病例强调了PBL在中东地区的罕见性,并突出了诊断和分类挑战,强调了准确技术在指导治疗决策中的核心作用。