Lalau J D, Arlot S, Quichaud J
Ann Med Interne (Paris). 1985;136(6):486-95.
There are two types of diabetic neuropathy: on the one hand, mononeuritis and, on the other hand, the symmetric polyneuropathy with a glove and stocking distribution and autonomic polyneuropathy. Mononeuritis (or mononeuritis multiplex) seems to be the result of ischaemia due to intrinsic or extrinsic (altered coagulability) vascular disease. Polyneuropathy is probably due to metabolic factors related to chronic hyperglycaemia: abnormal nerve energy metabolism, impaired axonal transport, increased activity of the sorbitol pathway, non-enzymatic nerve protein glucosylation and abnormal myo-inositol metabolism. The respective roles of these different factors in the pathogenesis of polyneuropathy are discussed.
一方面是单神经炎，另一方面是呈手套和袜套样分布的对称性多发性神经病变以及自主神经病变。单神经炎（或多发性单神经炎）似乎是由内在或外在（凝血功能改变）血管疾病导致的缺血所致。多发性神经病变可能归因于与慢性高血糖相关的代谢因素：神经能量代谢异常、轴突运输受损、山梨醇途径活性增加、神经蛋白非酶糖基化异常以及肌醇代谢异常。本文讨论了这些不同因素在多发性神经病变发病机制中的各自作用。
