College of Health and Life Sciences, Aston University, Birmingham, United Kingdom.
School of Optometry and Vision Science, University of New South Wales, Sydney, Australia.
Cont Lens Anterior Eye. 2024 Aug;47(4):102191. doi: 10.1016/j.clae.2024.102191. Epub 2024 Jun 29.
The aging eye undergoes the same progressive crosslinking which occurs throughout the body, resulting in increased rigidity of ocular connective tissues including the lens and the sclera which impact ocular functions. This offers the potential for a scleral treatment that is based on restoring normal biomechanical movements. Laser Scleral Microporation is a laser therapy that evaporates fractional areas of crosslinked tissues in the sclera, reducing ocular rigidity over critical anatomical zones of the accommodation apparatus, restoring the natural dynamic range of focus of the eye. Although controversial and challenged, an alternative theory for presbyopia is Schachar's theory that suggests a reduction in the space between the ciliary processes and the crystalline lens. Widening of this space with expansion bands has been shown to aid near vision in people with presbyopia, a technique that has been used in the past but seems to be obsolete now. The use of drugs has been used in the treatment of presbyopia, either to cause pupil miosis to increase depth of focus, or an alteration in refractive error (to induce myopia in one eye to create monovision). Drugs and laser ablation of the crystalline lens have been used with the aim of softening the hardened lens. Poor nutrition and excess exposure to ultraviolet light have been implicated in the onset of presbyopia. Dietary nutritional supplements, lifestyle changes have also been shown to improve accommodation and the question arises whether these could be harnessed in a treatment for presbyopia as well.
衰老的眼睛会经历与全身相同的渐进交联过程,导致眼组织包括晶状体和巩膜的连接组织刚性增加,从而影响眼功能。这为基于恢复正常生物力学运动的巩膜治疗提供了潜力。激光巩膜微穿孔是一种激光疗法,它蒸发巩膜中交联组织的分数区域,减少调节装置关键解剖区域的眼球刚性,恢复眼睛焦点的自然动态范围。尽管存在争议和挑战,但Schachar 的理论认为,远视的另一种理论表明睫状突之间的空间减少和晶状体。已经表明,用扩张带扩大这个空间可以帮助远视患者改善近视力,过去曾使用过这种技术,但现在似乎已经过时了。药物已用于治疗远视,要么引起瞳孔缩小以增加景深,要么改变屈光不正(在一只眼中诱导近视以产生单视)。已经使用药物和激光消融晶状体来软化硬化的晶状体。不良的营养和过多的紫外线暴露与远视的发生有关。饮食营养补充剂和生活方式的改变也被证明可以改善调节,因此出现了一个问题,即这些是否也可以用于远视的治疗。