Faculty of Life Science and Technology, Kunming University of Science and Technology, No. 727 Jingming South Road, Kunming 650500, Yunnan, China.
Medical School, Kunming University of Science and Technology, No. 727 Jingming South Road, Kunming 650500, Yunnan, China.
Cereb Cortex. 2024 Aug 1;34(8). doi: 10.1093/cercor/bhae319.
Drug addiction is a chronic and relapse brain disorder. Psychostimulants such as cocaine and amphetamine are highly addictive drugs. Abuse drugs target various brain areas in the nervous system. Recent studies have shown that the prefrontal cortex (PFC) plays a key role in regulating addictive behaviors. The PFC is made up of excitatory glutamatergic cells and gamma-aminobutyric acid (GABAergic) interneurons. Recently, studies showed that GABA level was related with psychostimulant addiction. In this review, we will introduce the role and mechanism of GABA and γ-aminobutyric acid receptors (GABARs) of the PFC in regulating drug addiction, especially in psychostimulant addiction.
药物成瘾是一种慢性、易复发的脑部疾病。可卡因和安非他命等苯丙胺类兴奋剂是高度成瘾性药物。滥用药物会靶向神经系统的各个脑区。最近的研究表明，前额叶皮层（prefrontal cortex，PFC）在调节成瘾行为方面起着关键作用。PFC 由兴奋性谷氨酸能细胞和γ-氨基丁酸（GABAergic）中间神经元组成。最近的研究表明，GABA 水平与精神兴奋剂成瘾有关。在这篇综述中，我们将介绍 PFC 中 GABA 和γ-氨基丁酸受体（GABARs）在调节药物成瘾，尤其是精神兴奋剂成瘾中的作用和机制。
