Xu Jie, Lu Yi
Key Laboratory of Modern Chinese Medicine Preparation of Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang, China.
Front Microbiol. 2025 Jun 13;16:1583562. doi: 10.3389/fmicb.2025.1583562. eCollection 2025.
The gut microbiota plays a crucial role in metabolic processes associated with host brain function. Emerging research is progressively uncovering the intricate and multifaceted relationship between the gut and the brain. The gut microbiota significantly influences immune responses, secondary metabolism, and symbiosis with the host, thereby facilitating the production of essential metabolites, neurotransmitters, and other neuroactive compounds that impact the development and treatment of central nervous system disorders. This article delineates the communication pathways and mechanisms linking the microbiota, gut, and brain, providing a comprehensive overview of current research on how the gut microbiota affects nervous system function. Furthermore, it examines factors that can alter the gut microbiota and influence metabolite profiles, as well as current intervention strategies aimed at enhancing gut-brain communication, mitigating adverse triggers that disrupt the gut microbiota, and minimizing neuro-pathological changes.
肠道微生物群在与宿主脑功能相关的代谢过程中起着关键作用。新兴研究正逐步揭示肠道与大脑之间复杂且多方面的关系。肠道微生物群显著影响免疫反应、次生代谢以及与宿主的共生关系，从而促进必需代谢物、神经递质和其他神经活性化合物的产生，这些物质会影响中枢神经系统疾病的发展和治疗。本文阐述了连接微生物群、肠道和大脑的通信途径及机制，全面概述了当前关于肠道微生物群如何影响神经系统功能的研究。此外，还探讨了能够改变肠道微生物群并影响代谢物谱的因素，以及旨在加强肠-脑通信、减轻破坏肠道微生物群的不良触发因素并将神经病理变化降至最低的当前干预策略。
