γ-氨基丁酸转氨酶抑制剂
GABA transaminase inhibitors.
作者信息
Ciesielski L, Simler S, Gensburger C, Mandel P, Taillandier G, Benoit-Guyod J L, Boucherle A, Cohen-Addad C, Lajzerowicz J
出版信息
Adv Exp Med Biol. 1979;123:21-41. doi: 10.1007/978-1-4899-5199-1_2.
In summary, several branched-chain fatty acids appeared to be competitive inhibitors of GABA-T and non-competitive inhibitors of SSADH. These compounds produce an increase in brain GABA level, and for two of these it was shown that the increase differs among various brain areas. An increase of GABA cannot be obtained by inhibition of SSADH. The increase in brain GABA seems to correlate with the anticonvulsant activity of branched-chain fatty acids.
总之，几种支链脂肪酸似乎是γ-氨基丁酸转氨酶（GABA-T）的竞争性抑制剂和琥珀酸半醛脱氢酶（SSADH）的非竞争性抑制剂。这些化合物会使大脑中γ-氨基丁酸（GABA）水平升高，其中两种化合物在不同脑区的升高情况有所不同。抑制SSADH无法使GABA水平升高。大脑中GABA的升高似乎与支链脂肪酸的抗惊厥活性相关。
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