4-氨基己-5-炔酸（γ-乙炔基γ-氨基丁酸），一种γ-氨基丁酸转氨酶的催化抑制剂，对体内脑γ-氨基丁酸代谢的影响。 - Suppr

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超能文献

The effect of 4-amino hex-5-ynoic acid (gamma-acetylenic GABA, gammma-ethynyl GABA) a catalytic inhibitor of GABA transaminase, on brain GABA metabolism in vivo.

作者信息

Jung M J, Lippert B, Metcalf B W, Schechter P J, Böhlen P, Sjoerdsma A

出版信息

J Neurochem. 1977 Apr;28(4):717-23. doi: 10.1111/j.1471-4159.1977.tb10618.x.

DOI:10.1111/j.1471-4159.1977.tb10618.x

PMID:894280

Abstract

摘要

相似文献

The effect of 4-amino hex-5-ynoic acid (gamma-acetylenic GABA, gammma-ethynyl GABA) a catalytic inhibitor of GABA transaminase, on brain GABA metabolism in vivo.4-氨基己-5-炔酸（γ-乙炔基γ-氨基丁酸），一种γ-氨基丁酸转氨酶的催化抑制剂，对体内脑γ-氨基丁酸代谢的影响。

J Neurochem. 1977 Apr;28(4):717-23. doi: 10.1111/j.1471-4159.1977.tb10618.x.

In vitro and in vivo effects on brain GABA metabolism of (S)-4-amino-5-fluoropentanoic acid, a mechanism-based inactivator of gamma-aminobutyric acid transaminase.（S）-4-氨基-5-氟戊酸（一种基于机制的γ-氨基丁酸转氨酶失活剂）对脑γ-氨基丁酸代谢的体外和体内影响

Life Sci. 1983 Jun 13;32(24):2717-23. doi: 10.1016/0024-3205(83)90391-0.

Audiogenic seizure protection by elevated brain GABA concentration in mice: effects of gamma-acetylenic gaba and gamma-vinyl GABA, two irreversible GABA-T inhibitors.小鼠脑内γ-氨基丁酸（GABA）浓度升高对听源性癫痫的保护作用：两种不可逆性GABA转氨酶（GABA-T）抑制剂——γ-乙炔基氨基丁酸和γ-乙烯基氨基丁酸的作用

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N-(5'-Phosphopyridoxyl)-4-aminobutyric acid: a stabel bisubstrate adduct inhibitor of rat brain 4-aminobutyric acid aminotransferase.N-（5'-磷酸吡哆醛基）-4-氨基丁酸：大鼠脑4-氨基丁酸转氨酶的一种稳定双底物加合物抑制剂。

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gamma-Vinyl GABA (4-amino-hex-5-enoic acid), a new selective irreversible inhibitor of GABA-T: effects on brain GABA metabolism in mice.

J Neurochem. 1977 Nov;29(5):797-802. doi: 10.1111/j.1471-4159.1977.tb10721.x.

Blockade of epileptic responses in the photosensitive baboon, Papio papio, by two irreversible inhibitors of GABA-transaminase, gamma-acetylenic GABA (4-amino-hex-5-ynoic acid) and gamma-vinyl GABA (4-amino-hex-5-enoic acid).两种不可逆的γ-氨基丁酸转氨酶抑制剂，γ-乙炔基γ-氨基丁酸（4-氨基-5-己炔酸）和γ-乙烯基γ-氨基丁酸（4-氨基-5-己烯酸）对光敏狒狒（豚尾狒狒）癫痫反应的阻断作用

Psychopharmacology (Berl). 1978 Sep 15;59(1):47-50. doi: 10.1007/BF00428029.

Effect of inhibitors of GABA transaminase on the synthesis, binding, uptake, and metabolism of GABA.γ-氨基丁酸转氨酶抑制剂对γ-氨基丁酸合成、结合、摄取及代谢的影响。

J Neurochem. 1980 Jun;34(6):1603-8. doi: 10.1111/j.1471-4159.1980.tb11250.x.

Effects of ethanolamine-O-sulphate and gamma-acetylenic-GABA on GABA content, GAD and GABA-T in various areas of chick brain after intraventricular microinjection.脑室微量注射乙醇胺 - O - 硫酸盐和γ - 乙炔基 - GABA 对雏鸡脑不同区域 GABA 含量、谷氨酸脱羧酶和 GABA 转氨酶的影响。

J Neurochem. 1979 Jul;33(1):343-6. doi: 10.1111/j.1471-4159.1979.tb11738.x.

The differential effects of GABA-transaminase inactivation in the chick retina and brain.

J Neurochem. 1982 Oct;39(4):1147-51. doi: 10.1111/j.1471-4159.1982.tb11508.x.

Bilateral asymmetry in brain GABA function?大脑γ-氨基丁酸（GABA）功能的双侧不对称性？

Neurosci Lett. 1981 Sep 1;25(2):167-72. doi: 10.1016/0304-3940(81)90326-8.

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Synchronization by food access modifies the daily variations in expression and activity of liver GABA transaminase.通过食物获取实现的同步化改变了肝脏γ-氨基丁酸转氨酶表达和活性的每日变化。

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4-amino-5-hexynoic Acid-a potent inhibitor of tetrapyrrole biosynthesis in plants.4-氨基-5-己炔酸——一种植物中四吡咯生物合成的有效抑制剂。

Plant Physiol. 1988 Nov;88(3):747-51. doi: 10.1104/pp.88.3.747.

Investigation of the antifibrillatory activity of some anticonvulsant gamma-aminobutyric acid-transaminase inhibitors in the rabbit isolated heart: comparison with phenytoin and mexiletine.某些抗惊厥γ-氨基丁酸转氨酶抑制剂对兔离体心脏抗纤颤活性的研究：与苯妥英和美西律的比较。

Br J Pharmacol. 1980;71(2):635-9. doi: 10.1111/j.1476-5381.1980.tb10984.x.

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