Elias Hafiza A, Mohib Khadija, Saleem Muhammad Asjad, Rajput Laraib Shabbir, Ellahi Aayat
Department of Medicine, Teklehaimanot General Hospital, Addis Ababa, ETH.
Department of Family Medicine, Tarzana Medical Group, Los Angeles, USA.
Cureus. 2024 Jul 4;16(7):e63792. doi: 10.7759/cureus.63792. eCollection 2024 Jul.
Traumatic brain injury (TBI) is a significant global health issue, contributing substantially to mortality and disability. Serum biomarkers, such as homocysteine (Hcy), play a critical role in the prognosis of brain injuries, with hyperhomocysteinemia (HHcy) potentially leading to neurological disorders. We present the case of a 64-year-old patient admitted to the emergency department following a road traffic accident (RTA). Magnetic resonance imaging (MRI) revealed parietal subdural hematoma (SDH), right frontal contusion, and left subarachnoid hemorrhage (SAH). The patient underwent a craniotomy to address SAH and SDH. Initial Hcy levels were markedly elevated compared to post-operative levels. Hcy represents a rapid, non-invasive, and cost-effective diagnostic tool for assessing brain injury severity and guiding medical intervention. Early detection of HHcy could potentially mitigate vascular and neurological complications, thereby improving patient outcomes.
创伤性脑损伤（TBI）是一个重大的全球健康问题，对死亡率和残疾率有重大影响。血清生物标志物，如同型半胱氨酸（Hcy），在脑损伤的预后中起关键作用，高同型半胱氨酸血症（HHcy）可能导致神经紊乱。我们报告一例64岁患者，在道路交通事故（RTA）后被送往急诊科。磁共振成像（MRI）显示顶叶硬膜下血肿（SDH）、右额叶挫伤和左蛛网膜下腔出血（SAH）。该患者接受了开颅手术以处理SAH和SDH。与术后水平相比，初始Hcy水平显著升高。Hcy是一种快速、无创且经济高效的诊断工具，用于评估脑损伤严重程度并指导医疗干预。早期检测HHcy可能会减轻血管和神经并发症，从而改善患者预后。
