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全球神经创伤研究的挑战与机遇。

Global neurotrauma research challenges and opportunities.

机构信息

Neuroscience Institute, Neurotrauma Group, El Bosque University, Avenue Carrera 9a, 131A-02, Edificio Fundadores, Bogotá, Colombia.

Department of Medical Informatics and Clinical Epidemiology, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, USA.

出版信息

Nature. 2015 Nov 19;527(7578):S193-7. doi: 10.1038/nature16035.

DOI:10.1038/nature16035
PMID:26580327
Abstract

Traumatic injury to the brain or spinal cord is one of the most serious public health problems worldwide. The devastating impact of 'trauma', a term used to define the global burden of disease related to all injuries, is the leading cause of loss of human potential across the globe, especially in low- and middle-income countries. Enormous challenges must be met to significantly advance neurotrauma research around the world, specifically in underserved and austere environments. Neurotrauma research at the global level needs to be contextualized: different regions have their own needs and obstacles. Interventions that are not considered a priority in some regions could be a priority for others. The introduction of inexpensive and innovative interventions, including mobile technologies and e-health applications, focused on policy management improvement are essential and should be applicable to the needs of the local environment. The simple transfer of a clinical question from resource-rich environments to those of low- and middle-income countries that lack sophisticated interventions may not be the best strategy to address these countries' needs. Emphasis on promoting the design of true 'ecological' studies that include the evaluation of human factors in relation to the process of care, analytical descriptions of health systems, and how leadership is best applied in medical communities and society as a whole will become crucial.

摘要

颅脑或脊髓创伤是全球最严重的公共卫生问题之一。“创伤”一词用于定义与所有损伤相关的全球疾病负担,其具有破坏性的影响是全球范围内人类潜能丧失的主要原因,尤其是在低收入和中等收入国家。要想在全球范围内显著推进神经创伤研究,特别是在服务不足和艰苦环境中,必须应对巨大的挑战。全球层面的神经创伤研究需要具体情况具体分析:不同地区有其自身的需求和障碍。在某些地区不被视为优先事项的干预措施,在其他地区可能是优先事项。引入廉价且创新的干预措施,包括移动技术和电子健康应用程序,以改善政策管理,这是至关重要的,并且应该适用于当地环境的需求。简单地将一个临床问题从资源丰富的环境转移到缺乏复杂干预措施的低收入和中等收入国家,可能不是解决这些国家需求的最佳策略。强调促进真正“生态”研究的设计,包括评估与护理过程相关的人为因素、对卫生系统的分析描述,以及如何在医学社区和整个社会中最好地应用领导力,将变得至关重要。

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Priorities and Concerns for Research on Neurotrauma in the Developing World.发展中世界神经创伤研究的重点与关切
Bull Emerg Trauma. 2013 Jan;1(1):5-6.
2
Pressure ulcers in people with spinal cord injury in developing nations.发展中国家脊髓损伤患者的压疮
Spinal Cord. 2015 Jan;53(1):7-13. doi: 10.1038/sc.2014.179. Epub 2014 Nov 4.
3
Global prevalence and incidence of traumatic spinal cord injury.全球创伤性脊髓损伤的患病率和发病率。
硬膜外电刺激促进不完全性脊髓损伤功能恢复
Cyborg Bionic Syst. 2025 Jul 22;6:0314. doi: 10.34133/cbsystems.0314. eCollection 2025.
4
Global insights into traumatic brain injury. The low- and middle-income countries' perspective.对创伤性脑损伤的全球洞察。低收入和中等收入国家的视角。
Crit Care Sci. 2025 Jul 11;37:e20250255. doi: 10.62675/2965-2774.20250255. eCollection 2025.
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Fast and Slow Recovery of Consciousness Following Traumatic Brain Injury.创伤性脑损伤后意识的快速与缓慢恢复
Neurocrit Care. 2025 Jun 27. doi: 10.1007/s12028-025-02304-2.
6
Fiber tract integrity in patients with brain injury and chronic health symptoms.脑损伤和慢性健康症状患者的纤维束完整性
Neuroimage Rep. 2021 Sep 13;1(4):100047. doi: 10.1016/j.ynirp.2021.100047. eCollection 2021 Dec.
7
Multidimensional exploration of hydrogels as biological scaffolds for spinal cord regeneration: mechanisms and future perspectives.水凝胶作为脊髓再生生物支架的多维探索:机制与未来展望
Front Bioeng Biotechnol. 2025 Apr 23;13:1576524. doi: 10.3389/fbioe.2025.1576524. eCollection 2025.
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Intranasal Delivery of Brain-Derived Neurotrophic Factor (BDNF)-Loaded Small Extracellular Vesicles for Treating Acute Spinal Cord Injury in Rats and Monkeys.经鼻递送负载脑源性神经营养因子(BDNF)的小细胞外囊泡用于治疗大鼠和猴子的急性脊髓损伤
J Extracell Vesicles. 2025 Apr;14(4):e70066. doi: 10.1002/jev2.70066.
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Sci Adv. 2025 Apr 4;11(14):eads3398. doi: 10.1126/sciadv.ads3398. Epub 2025 Apr 2.
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Ann Med Surg (Lond). 2025 Jan 7;87(2):673-683. doi: 10.1097/MS9.0000000000002901. eCollection 2025 Feb.
Clin Epidemiol. 2014 Sep 23;6:309-31. doi: 10.2147/CLEP.S68889. eCollection 2014.
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Is intracranial pressure monitoring still required in the management of severe traumatic brain injury? Ethical and methodological considerations on conducting clinical research in poor and low-income countries.在重度创伤性脑损伤的管理中是否仍需要进行颅内压监测?关于在贫困和低收入国家开展临床研究的伦理和方法学考量。
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A standardized trauma care protocol decreased in-hospital mortality of patients with severe traumatic brain injury at a teaching hospital in a middle-income country.在一个中等收入国家的一家教学医院,标准化创伤护理方案降低了重度创伤性脑损伤患者的院内死亡率。
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Advancing care for traumatic brain injury: findings from the IMPACT studies and perspectives on future research.推进创伤性脑损伤的护理:IMPACT 研究的结果及对未来研究的展望。
Lancet Neurol. 2013 Dec;12(12):1200-10. doi: 10.1016/S1474-4422(13)70234-5. Epub 2013 Oct 17.