Kumar Sathish, Pandey Jagjit, Bharti Shreekant, Senapati Satyanarayanan
Surgical Oncology, All India Institute of Medical Sciences, Patna, Patna, IND.
Pathology, All India Institute of Medical Sciences, Patna, Patna, IND.
Cureus. 2024 Jul 3;16(7):e63751. doi: 10.7759/cureus.63751. eCollection 2024 Jul.
Introduction Squamous cell carcinoma (SCC) comprises more than 90% of malignant tumors of the oral cavity, accounting for up to 40% of all malignancies in South Asia. Despite the progress made in cancer management, the five-year survival rate for SCC has remained around 50%. To improve this survival rate, it is essential to understand the tumor's biology at its core. In our study, the Ki-67 proliferation index of tumor cells was analyzed and correlated with the tumor stage, nodal stage, and tumor grade to determine the tumor's biological aggressiveness. Materials and methods The study was conducted in a tertiary care center in South Asia from 2018 to 2022. A total of 50 adult patients with biopsy-proven oral cavity SCC were taken for analysis. The Ki-67 index was assessed in tumor cells using immunohistochemistry. Results Ki-67 was classified into two subcategories: <20% and >20%. Patients with an advanced T stage (T3-T4) have a greater chance of having a higher Ki-67 index (>20%), with p = 0.047. However, there is no statistically significant association between nodal status and tumor grade. Conclusion The Ki-67 proliferation index predicts the behavior of SCC lesions regarding tumor size and invasiveness.
引言
鳞状细胞癌（SCC）占口腔恶性肿瘤的90%以上，在南亚占所有恶性肿瘤的40%。尽管癌症治疗取得了进展，但SCC的五年生存率仍维持在50%左右。为提高这一生存率，从核心层面了解肿瘤生物学特性至关重要。在我们的研究中，分析了肿瘤细胞的Ki-67增殖指数，并将其与肿瘤分期、淋巴结分期和肿瘤分级相关联，以确定肿瘤的生物学侵袭性。
材料与方法
该研究于2018年至2022年在南亚的一家三级医疗中心进行。共纳入50例经活检证实为口腔SCC的成年患者进行分析。采用免疫组织化学方法评估肿瘤细胞中的Ki-67指数。
结果
Ki-67分为两个亚类：<20%和>20%。T分期较晚（T3-T4）的患者有更高的Ki-67指数（>20%）的可能性更大，p = 0.047。然而，淋巴结状态与肿瘤分级之间无统计学显著关联。
结论
Ki-67增殖指数可预测SCC病变在肿瘤大小和侵袭性方面的行为。
