Bettendorf O, Piffkò J, Bànkfalvi A
Institute of Pathology, University of Münster, Domagkstrabetae 17, 48149 Münster, Germany.
Oral Oncol. 2004 Feb;40(2):110-9. doi: 10.1016/j.oraloncology.2003.08.010.
An escalation in the incidence of oral cancer and its attributable mortality has been observed in recent decades in Europe; oral cancer is expected to become a public health problem in the foreseeable future. However, survival rates have remained at a disappointingly stable level despite significant development in the multimodality treatment of the disease. Additionally, due to the limited prognostic value of conventional prognostic factors and the uniformity of treatment strategies, several patients are still over- or under-treated with significant personal and socio-economical impact. Here we review some promising prognostic and predictive markers that can help the clinician to improve prognostic accuracy and define the most appropriate management for the individual patient with oral cancer.
近几十年来，欧洲口腔癌的发病率及其所致死亡率呈上升趋势；预计在可预见的未来，口腔癌将成为一个公共卫生问题。然而，尽管该疾病的多模式治疗取得了显著进展，但其生存率仍一直处于令人失望的稳定水平。此外，由于传统预后因素的预后价值有限以及治疗策略的一致性，一些患者仍接受过度或不足的治疗，这对个人和社会经济产生了重大影响。在此，我们综述了一些有前景的预后和预测标志物，它们有助于临床医生提高预后准确性，并为口腔癌个体患者确定最合适的治疗方案。
