腺苷对从链脲佐菌素诱导的糖尿病大鼠分离的脂肪细胞葡萄糖氧化的影响。
Adenosine effects on glucose oxidation of adipocytes isolated from streptozotocin-diabetic rats.
作者信息
Wong E H, Smith J A, Jarett L
出版信息
Biochem J. 1985 Nov 15;232(1):301-4. doi: 10.1042/bj2320301.
Abstract
Streptozotocin-induced diabetes did not impair the response of adipocytes to adenosine effects in glucose oxidation. The greatest effect of adenosine in potentiating the action of insulin was in the physiological concentration range of insulin (10-100 mu units/ml). The desensitization of cells by diabetes to the effects of insulin is therefore probably not related to the response of cells to adenosine.
摘要
链脲佐菌素诱导的糖尿病并未损害脂肪细胞对腺苷在葡萄糖氧化方面作用的反应。腺苷增强胰岛素作用的最大效应出现在胰岛素的生理浓度范围（10 - 100微单位/毫升）内。因此，糖尿病导致细胞对胰岛素作用的脱敏可能与细胞对腺苷的反应无关。
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