Lisevski Caroline Inês, Morais Alysson Ferreira, Aguero Natasha Fioretto, Teixeira Alexandre Candido, Moreira Ribeiro Francisco Wanderson, Correra Thiago Carita, Guide Nunes da Silva Ivan, Mustafa Danilo
Instituto de Física da Universidade de São Paulo, 05508-090 São Paulo, SP, Brazil.
Center for Surface Chemistry and Catalysis, KU Leuven, B-3001 Leuven, Belgium.
ACS Omega. 2024 Jul 17;9(30):32962-32968. doi: 10.1021/acsomega.4c03934. eCollection 2024 Jul 30.
The organic compound niacin or nicotinic acid, also known as vitamin B (VitB), is essential for human nutrition and metabolic regulation. However, in high doses, it can provoke side effects, such as hyperglycemia, liver damage, and flushing. Development of a controlled release system that slowly releases VitB into the organism would avoid high dosing peaks, thus contributing to decrease the occurrence of side effects in nutritional supplementation. Here, we show that the slow and controlled release of VitB in an acid environment can be achieved via its intercalation in layered double hydroxides (LDHs). The synthesis of a ZnAl-VitB system is shown, in which VitB is intercalated in a ZnAl LDH. The presence of VitB in the ZnAl-VitB system was confirmed by elemental analysis, infrared (FTIR) and NMR spectroscopy, while successful intercalation in the LDHs was revealed by powder X-ray diffraction (PXRD). In vitro release tests were carried out in a concentrated HCl solution of pH 1.5, a pH similar to the human stomach environment. The results showed a steady release of VitB from the LDH host, with 90% of the vitamin liberated in the first 60 min after the suspension of the LDH in the acidic solution.
有机化合物烟酸或尼克酸，也称为维生素B（VitB），对人体营养和代谢调节至关重要。然而，高剂量时，它会引发副作用，如高血糖、肝损伤和脸红。开发一种能将VitB缓慢释放到生物体内的控释系统，将避免高剂量峰值，从而有助于减少营养补充中副作用的发生。在此，我们表明，通过将VitB插层到层状双氢氧化物（LDHs）中，可以在酸性环境中实现VitB的缓慢和控释。展示了一种ZnAl-VitB系统的合成，其中VitB插层在ZnAl LDH中。通过元素分析、红外（FTIR）和NMR光谱证实了ZnAl-VitB系统中VitB的存在，而粉末X射线衍射（PXRD）揭示了其在LDHs中的成功插层。在pH 1.5的浓盐酸溶液（类似于人体胃部环境的pH值）中进行了体外释放试验。结果显示，VitB从LDH主体中稳定释放，在将LDH悬浮于酸性溶液后的前60分钟内，90%的维生素被释放出来。
