Chen Kitty Y A, van Ingen Trevor, Smith Brendan T, Fitzpatrick Tiffany, Whelan Michael, Parpia Alyssa S, Alessandrini Jenna, Buchan Sarah A
Public Health Ontario, Toronto, Ontario, Canada.
Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.
Open Forum Infect Dis. 2024 Jul 10;11(8):ofae384. doi: 10.1093/ofid/ofae384. eCollection 2024 Aug.
Beyond clinical risk factors, little is known about the impact of social determinants on respiratory syncytial virus (RSV) burden. Our study aimed to estimate RSV-related hospitalization rates across sociodemographic and housing characteristics.
We conducted a population-based study of all RSV-related hospitalizations in Ontario, Canada, between September 1, 2016, and August 31, 2019, using validated hospital discharge codes and census data. Crude and age-standardized annualized RSV incidence rates and rate ratios (RRs) were estimated for a range of individual-level demographics and neighborhood-level measures of marginalization and housing characteristics.
Overall, the annual RSV-related hospitalization rate was 27 per 100 000, with the highest rates observed in children age <12 months (1049 per 100 000) and 12-23 months (294 per 100 000) and adults age ≥85 years (155 per 100 000). Higher RSV-related hospitalization rates were associated with increasing marginalization quintile (Q) of material resources (RR, 1.4; Q5: 33 per 100 000 vs Q1: 24 per 100 000) and household instability (RR, 1.5; Q5: 31 per 100 000 vs Q1: 22 per 100 000).
The burden of RSV-related hospitalization was greatest in young children and older adults, with variation by sociodemographic and housing factors. Understanding the role of these social factors is crucial for informing equitable preventive program delivery.
除了临床风险因素外，关于社会决定因素对呼吸道合胞病毒（RSV）负担的影响知之甚少。我们的研究旨在估计不同社会人口统计学和住房特征下与RSV相关的住院率。
我们利用经过验证的医院出院编码和人口普查数据，对2016年9月1日至2019年8月31日期间加拿大安大略省所有与RSV相关的住院病例进行了一项基于人群的研究。针对一系列个体层面的人口统计学特征以及邻里层面的边缘化和住房特征指标，估计了粗发病率和年龄标准化的年化RSV发病率及率比（RRs）。
总体而言，与RSV相关的年住院率为每10万人27例，在年龄小于12个月的儿童（每10万人1049例）、12至23个月的儿童（每10万人294例）和85岁及以上的成年人（每10万人155例）中观察到的发病率最高。与RSV相关的住院率较高与物质资源边缘化五分位数（Q）增加（RR，1.4；Q5：每10万人33例 vs Q1：每10万人24例）和家庭不稳定（RR，1.5；Q5：每10万人31例 vs Q1：每10万人22例）相关。
与RSV相关的住院负担在幼儿和老年人中最大，且因社会人口统计学和住房因素而有所不同。了解这些社会因素的作用对于制定公平的预防计划至关重要。
