固有免疫细胞在结直肠癌肿瘤微环境中的作用及抗肿瘤治疗研究进展。
The role of innate immune cells in the colorectal cancer tumor microenvironment and advances in anti-tumor therapy research.
机构信息
Department of General Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei, China.
出版信息
Front Immunol. 2024 Jul 19;15:1407449. doi: 10.3389/fimmu.2024.1407449. eCollection 2024.
Abstract
Innate immune cells in the colorectal cancer microenvironment mainly include macrophages, neutrophils, natural killer cells, dendritic cells and bone marrow-derived suppressor cells. They play a pivotal role in tumor initiation and progression through the secretion of diverse cytokines, chemokines, and other factors that govern these processes. Colorectal cancer is a common malignancy of the gastrointestinal tract, and understanding the role of innate immune cells in the microenvironment of CRC may help to improve therapeutic approaches to CRC and increase the good prognosis. In this review, we comprehensively explore the pivotal role of innate immune cells in the initiation and progression of colorectal cancer (CRC), alongside an extensive evaluation of the current landscape of innate immune cell-based immunotherapies, thereby offering valuable insights for future research strategies and clinical trials.
摘要
结直肠癌微环境中的固有免疫细胞主要包括巨噬细胞、中性粒细胞、自然杀伤细胞、树突状细胞和骨髓来源的抑制细胞。它们通过分泌多种细胞因子、趋化因子和其他调节这些过程的因子，在肿瘤的发生和进展中发挥关键作用。结直肠癌是一种常见的胃肠道恶性肿瘤，了解固有免疫细胞在 CRC 微环境中的作用可能有助于改善 CRC 的治疗方法，并提高良好的预后。在这篇综述中，我们全面探讨了固有免疫细胞在结直肠癌（CRC）发生和进展中的关键作用，并广泛评估了基于固有免疫细胞的免疫疗法的现状，为未来的研究策略和临床试验提供了有价值的见解。
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