Liu Siyu, Sun Chen, Tang Hailin, Peng Cheng, Peng Fu
State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China.
Front Pharmacol. 2024 Jul 19;15:1428406. doi: 10.3389/fphar.2024.1428406. eCollection 2024.
Leonurine is an alkaloid unique to the genus, which has many biological activities, such as uterine contraction, anti-inflammation, anti-oxidation, regulation of cell apoptosis, anti-tumor, angiogenesis, anti-platelet aggregation, and inhibition of vasoconstriction. This paper summarizes the extraction methods, synthetic pathways, biosynthetic mechanisms, pharmacokinetic properties, pharmacological effects in various diseases, toxicology, and clinical trials of leonurine. To facilitate a successful transition into clinical application, intensified efforts are required in several key areas: structural modifications of leonurine to optimize its properties, comprehensive pharmacokinetic assessments to understand its behavior within the body, thorough mechanistic studies to elucidate how it works at the molecular level, rigorous safety evaluations and toxicological investigations to ensure patient wellbeing, and meticulously conducted clinical trials to validate its efficacy and safety profile.
益母草碱是该属特有的一种生物碱，具有多种生物活性，如子宫收缩、抗炎、抗氧化、调节细胞凋亡、抗肿瘤、血管生成、抗血小板聚集以及抑制血管收缩等。本文综述了益母草碱的提取方法、合成途径、生物合成机制、药代动力学性质、在各种疾病中的药理作用、毒理学以及临床试验。为了顺利过渡到临床应用，需要在几个关键领域加大力度：对益母草碱进行结构修饰以优化其性质，进行全面的药代动力学评估以了解其在体内的行为，开展深入的机制研究以阐明其在分子水平的作用方式，进行严格的安全性评估和毒理学调查以确保患者健康，以及精心开展临床试验以验证其疗效和安全性。
