麦冬皂苷D：药理活性综述
Ophiopogonin D: review of pharmacological activity.
作者信息
Chen Ke-Qian, Wang Shu-Zhi, Lei Hai-Bo, Liu Xiang
机构信息
Department of Clinical Pharmacy, Xiangtan Central Hospital, Xiangtan, China.
Institute of Pharmacy and Pharmacology, School of Pharmaceutical Sciences, Hengyang Medical School, University of South China, Hengyang, China.
出版信息
Front Pharmacol. 2024 Jul 18;15:1401627. doi: 10.3389/fphar.2024.1401627. eCollection 2024.
BACKGROUND
Ophiopogon D is an important natural organic compound in , which often has significant biological activity.
PURPOSE
The purpose of this review is to systemically summarize and discuss the pharmacological activity and underlying mechanisms of OP-D in recent years.
METHOD
PubMed and Web of Science were searched with the keywords:"", "Ophiopogon D" "pharmacology", and "pharmacokinetics". There was no restriction on the publication year, and the last search was conducted on 1 Jan 2024.
RESULTS
Emerging evidence suggests that OP-D possess numerous pharmacological activities, including bone protection, cardiovascular protection, immune regulation, anti-cancer, anti-atherosclerosis, anti-inflammatory and anti-NAFLD.
CONCLUSION
OP-D has a potential value in the prevention and treatment of many diseases. We hope that this review will contribute to therapeutic development and future studies of OP-D.
背景
麦冬苷D是麦冬中的一种重要天然有机化合物，通常具有显著的生物活性。
目的
本综述旨在系统总结和讨论近年来麦冬苷D的药理活性及其潜在机制。
方法
以“麦冬苷D”“药理学”和“药代动力学”为关键词，在PubMed和Web of Science数据库中进行检索。对发表年份没有限制，最后一次检索于2024年1月1日进行。
结果
新出现的证据表明，麦冬苷D具有多种药理活性，包括骨骼保护、心血管保护、免疫调节、抗癌、抗动脉粥样硬化、抗炎和抗非酒精性脂肪性肝病。
结论
麦冬苷D在多种疾病的预防和治疗中具有潜在价值。我们希望本综述将有助于麦冬苷D的治疗开发和未来研究。
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